Automatic Ampoule Washer

Description

Automatic Ampoule Washer is specifically made to clean Ampoule with Minimum Contact Machine Parts. With the use of replacement parts, the machine can wash 1 ml to 20 ml ampoules. The pharmaceutical, veterinary, and biotech industries all make extensive use of automatic rotary ampoule washing systems. Once the ampoule has been effectively cleaned, the gripper releases it into the outfeed feed worm system in a vertical posture until the ampoules have been positively washed. After that, the ampoule is in charge of feeding the feed worm onto the star wheel. The ampoule is then held and inverted by the specifically made gripper before being placed on the rotational moving system for the washing procedure.

One of the best products available is the Automatic Ampoule washer, which has several amazing characteristics. This long-lasting machine is ideal for use in pharmaceutical manufacturing facilities because it is made of premium stainless steel. This machine’s automatic grade system is intended to increase productivity and optimise your production process. The machine is capable of handling even the most difficult duties since it runs at a frequency of 50–60 Hertz (HZ) and a voltage of 220–440 Volt (v). This machine has a straightforward interface that lets you get started right away, and despite its amazing capabilities, it is surprisingly simple to use.

Working Principle of Automatic Ampoule Washer

Ampoules feed from the Infeed tray are received on an Infeed Feed worm then moves on Infeed starwheel. The Grippers picks up the Ampoule from Infeed Star Wheel and invert it in neck down position over washing needles and move along with the needle bar for Washing. Ampoules traveling in neck down position above washing needles and moves along with the Needle bar ensures maximum time for washing once the needle enter in the Ampoule neck. Machine having six different washing stations each of 6 needles for optimum Washing and the sequence can be adjusted as per requirements. Washer also having external wash for optimum washing of ampoules.

On completion of a cycle, washed Ampoules are again inverted to neck upward position and feed to output star wheel. Washed Ampoules received from output starwheel can be collected on Output Tray or can be pushed to tunnel. A separate pumping station (optional) gives the right quantum of water at the desired pressure. In the absent of separate pumping station, we can provide the re-circulation & siliconization system on request.

INTERNAL CLEANING:

The AVRW is equipped with 6 internal cleaning stations and each station has 6 cleaning needles making up a total of 36 cleaning needles. Each cleaning station is supplied via a pipe connected to the cleaning media-making washing area. This not only reduces the risk of particle generation, but also simplifies maintenance and cleaning efforts while saving time.

 

EXTERNAL CLEANING

The 3 external cleaning stations mounted in a stationary position above the ampoule can be easily adjusted for a specific height, angle and lateral position. Each cleaning station receives cleaning media-making through a pipe connected to the cleaning media-making washing area.

 

CLEANING MEDIA PRINCIPAL:

WFI, Purified water and air cleaning station are synchronized with the ampoule by reciprocating motion. Design is such that these media are put to use only when needles motion in forward direction. WFI consumption is further reduced by collecting the WFI in re-circulating water tank to be used later on in the pre-washing station.

Technical Specification of Automatic Ampoule Washer

Model

AVRW 120

AVRW 240

Production Output

Up to 100 per minute

Up to 200 per minute

Ampoule Diameter

9mm to 21.5mm

9mm to 21.5mm

Ampoule Height

60mm to 140mm

60mm to 140mm

Power Load

4 H.P.

5.5 H.P.

Power Voltage

440 Volts, 3 Phase 50 Hertz, 4 wire system

440 Volts, 3 Phase 50 Hertz, 4 wire system.

Optional Accessories

  • Programmable Logic Control (System) with HMI
  • Safety Cabinet with doors
  • Programmable Logic Control (System) with HMI
  • Safety Cabinet with doors

Utility

  • Air – 20 CFM
  • Water – 200 to 500 liters per hour depend upon ampoule size.
  • Air – 20 CFM
  • Water – 200 to 500 liters per hour depend upon ampoule size.

Water Tank & Pump

3 nos. each with 25 liters Capacity & Centrifugal pump

3 nos. each with 25 liters Capacity & Centrifugal pump

Overall Dimension:

2050mm (L) X 2000mm (W) X 1210mm (H) approx.

2450mm (L) X 2000mm (W) X 1300mm (H) approx.

Net Weight

700 kgs. approx.

900 kgs. approx.

Gross Weight

1000 kgs. approx.

1300 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Washing Machine

Applications of Automatic Ampoule Washer

Advantages of Automatic Ampoule Washer

Ensures sterility and compliance with cGMP and FDA standards.

High efficiency with minimal operator intervention.

Customizable washing sequences and compatibility with various ampoule sizes.

Reduces contamination risks through minimal contact and advanced filtration systems.

Washing Cycle of Automatic Ampoule Washer

1st wash           

Recycled Water (WFI)

2nd wash

Compressed Air

3rd wash          

DM Water

4th wash

Compressed Air

5th wash

Water for Injection (WFI)

6th wash

Compressed Air

Design and Operation of Automatic Ampoule Washer

  • Structure: The machine features a compact, enclosed design, typically constructed with AISI 316L stainless steel for contact parts and AISI 304 or FDA-approved engineering plastics for non-contact parts, ensuring durability and hygiene.

 

  • Gripper System: A specially designed gripper system holds ampoules by their necks, inverts them for washing, and releases them in a vertical position post-washing, ensuring positive and thorough cleaning with minimal contact.

 

  • Rotary Motion: Ampoules are fed via an infeed hopper or tray, aligned by a feedworm, and transferred to an infeed starwheel. The rotary system moves ampoules continuously or via indexing motion through multiple washing stations.

 

  • Washing Process:
    • Ampoules are inverted (neck down) over washing needles, which enter the ampoule neck for internal cleaning.
    • Spray tubes or nozzles, synchronized with ampoule movement, deliver cleaning media (e.g., Water for Injection (WFI), purified water, or compressed air) to internal and external surfaces.
    • The machine typically features 6 washing stations, each with 6–8 needles (totaling 36–48 needles), providing 3–6 internal water washes (e.g., recycled water, purified water, WFI) and 3 air washes, plus 1–2 external water and air washes.
    • Washing sequences are customizable to meet specific requirements, with independent circuits for each washing zone to avoid cross-contamination.

 

  • Output and Re-inversion: After washing, ampoules are re-inverted to a neck-up position, discharged via an output starwheel, and collected on trays or fed directly to a sterilizing tunnel. Optional pumping stations ensure precise water pressure, while recirculation systems reduce WFI consumption.

Key Features of Automatic Ampoule Washer

  • Material: Contact parts are made of AISI 316L stainless steel, while non-contact parts use AISI 304 or FDA-approved materials, ensuring durability and cGMP compliance.

 

  • High Throughput: Capable of washing 50–400 ampoules per minute, depending on the model.

 

  • Automation and Control: Equipped with PLC systems and user-friendly HMIs for precise control, monitoring, and password-protected settings. Features include digital speed indicators and container counters.

 

  • Flexibility: Accommodates ampoule sizes from 1 ml to 20 ml (some up to 100 ml) with change parts for different sizes.

 

  • Low Water Consumption: Uses 200–500 liters/hour, depending on ampoule size, with optional recirculation systems.

 

  • Safety and Maintenance: Includes protective enclosures, emergency stop functions, and easy-to-dismantle components for cleaning and maintenance.

FAQ for Automatic Ampoule Washer

The Automatic Ampoule Washer is widely used in the pharmaceutical industry for cleaning ampoules before filling injectable drugs, vaccines, and sterile solutions. It is also suitable for:

  • Biotechnology
  • Veterinary medicines
  • Cosmetic industry (injectable serums)
  • Chemical industry

It can be used as a standalone machine or integrated inline with a sterilizing tunnel and filling machine.

The machine is available in two models:

  • AVRW 120: Up to 100 ampoules per minute
  • AVRW 240: Up to 200 ampoules per minute

It handles 1 ml to 10 ml ampoules (extendable up to 20 ml with change parts). Size range: Diameter 9 mm to 21.5 mm, Height 60 mm to 140 mm. Changeover is quick using interchangeable parts, and production speed is adjustable with a digital indicator.

The Automatic Ampoule Washer provides 6 internal washing stations (3 water + 3 air washes) with 36 needles (6 needles per station) and 3 external cleaning stations. Standard washing sequence (fully adjustable):

  • Recycled Water / WFI → Compressed Air
  • DM / Purified Water → Compressed Air
  • Final WFI → Final Compressed Air

Key features include:

  • Advanced gripper system (15 cassettes with 2 grippers each) for inverted neck-down washing
  • Independent washing circuits per zone to prevent cross-contamination
  • All contact parts in AISI 316L Stainless Steel
  • Digital speed indicator, container counter, and optional PLC with HMI + 21 CFR Part 11
  • Recirculation system for low WFI consumption
  • cGMP design with IQ/OQ/DQ documentation

Built as a complete cGMP model, the machine uses AISI 316L Stainless Steel for all product-contact parts and SS 304 or FDA-approved plastics for non-contact parts. Minimum container contact, independent washing zones, and inverted washing reduce contamination risks significantly. It meets stringent FDA and cGMP standards for sterile injectable production. Optional features include 21 CFR Part 11 compliant software, safety cabinet, and full validation documents, ensuring high sterility, operator safety, and easy regulatory approval.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

Contact Us

©Adinath International | Theme Developed By Pharma Machinery Manufacturer