Double Stroke Ampoule Filling Machine

Q: What are the main benefits of using a Double Stroke Ampoule Filling Machine?

Higher output — Double-head design delivers up to 50 ampoules/minute in a compact footprint. Excellent accuracy & minimal wastage — ±1% filling accuracy with “No Ampoule – No Fill” interlock. Superior sterility — Multi-stage nitrogen flushing and hermetic flame sealing protect sensitive injectables. Easy operation & maintenance — Quick changeover, full accessibility, low power consumption (0.5 HP), and user-friendly design. Versatility — Handles 1–30 ml ampoules and suits small-to-medium batch production while meeting FDA/cGMP standards.

Description

Double Stroke Ampoule Filling Machine (Double Head Ampoule Filler) is a two-head ampoule filling machine constructed from premium 316L stainless steel in accordance with cGMP regulations. All of the main unit drives are synchronised with a single motor, and a speed port is available for modifying speed. possesses both the pre and post-nitrogen flushing units and a nitrogen-flushing mechanism. The equipment’s ability to change ampoules as seldom as possible is one of its main advantages. In addition, an active pre-heating unit for thick glass ampoules is a feature of glass tube filler equipment. This machine is appropriate for filling ampoules in the chemical, pharmaceutical, cosmetic, and agricultural sectors.

A machine that can fill seal ampoules with a volume of 1 ml to 30 ml. In addition, the machine has a special filling capacity of 0.5 to 25 millilitres in a single dosage. The gadget can fill 10 to 250 ampoules per minute using the volumetric piston-pumps type filling concept. The dead-tray’s availability is another special benefit of this apparatus. It provides ideal diversion of the filled and sealed ampoules.

Oxygen and LPG (propane) are the gases needed to fill or seal the ampoules. The creation of ampoules containing veterinary medications, cosmetic ampoules, agro-insecticides, and a number of other substances is made as flexible as possible with this cutting-edge device. For all types of open-mouth glass ampoules, our Adinath line of Filler Sealer is ideal.

Salient Features of Double Stroke Ampoule Filling Machine

Compact model as per cGMP standard.
Higher output up to 3000 Ampoules per hour.
Machine equipped with pre-warming station.
“No Ampoule – No Filling” system.
Flow Meters for regulating flames easily.
Full accessibility allows easy maintenance.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Ampoule neck centering during gas flushing and filling operations.
Minimum change over parts from 1ml to 10ml ampoule size.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Double Stroke Ampoule Filling Machine

Empty washed & sterilized ampoules receive automatically on wire mesh conveyor belt from outfeed of sterilizing tunnel. Ampoule fed automatically into in-feed hopper from the left hand side of the machine and feed to receiving rack through cassette. The moving rack which moves horizontally collect two ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position through pre-gassing. Pre-gassing, Filling, Post Gassing, Pre-heating & sealing sta.

Technical Specification of Double Stroke Ampoule Filling Machine

Model Name	AFS-2
Production Speed	Up to 50 ampules/minute
Ampoule Sizes	1 ml to 30 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	0.5 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	915mm (L) x 760mm (W) x 965mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Benefits of Double Stroke Ampoule Filling Machine

High precision and efficiency with minimal product loss.

Compact design requiring less floor space, ideal for small to medium-scale facilities.

Customizable filling mechanisms (piston, servo, or peristaltic) to meet specific needs.

Robust, durable construction for long-term use with minimal upkeep.

Energy-efficient with automated features to streamline production.

Key Features of Double Stroke Ampoule Filling Machine

Construction: Made with a stainless steel (SS) square pipe frame and SS 316L contact parts for durability and compliance with cGMP standards. Non-contact parts are typically SS 304, with a matte finish for aesthetic appeal and ease of cleaning.

Filling Capacity: Suitable for filling 1ml to 25ml ampoules, with a dosing range of 0.5ml to 25ml per cycle. It operates using volumetric piston pumps, servo-driven pumps, or peristaltic pumps, depending on customization.

Output: Capable of filling 30 to 90 ampoules per minute (approximately 1,800 to 5,400 ampoules per hour), ideal for small to medium-scale production.

Operation: Fully automatic with minimal human intervention. Ampoules are loaded into an in-feed hopper, transferred via a synchronized star wheel to a transport rack, and moved through sequential stations:
- Pre-Nitrogen Flushing: Inert gas (nitrogen) is flushed to reduce oxygen exposure.
- Filling: Two filling heads discharge precise liquid volumes, with neck centering for accuracy.
- Post-Nitrogen Flushing: Additional nitrogen flush to maintain sterility.
- Pre-Heating: A low-pressure flame warms ampoules for sealing.
- Sealing: Uses oxygen and LPG (propane) with specially designed rollers for uniform sealing of open or closed-type ampoules (Type B and C).

Sealing Process: Features a two-stage sealing system (pre-heating and final sealing) to ensure clean, precise seals. Waste tips are collected in a high-quality SS container.

Flexibility: Minimal changeover parts required for different ampoule sizes (1ml to 20ml or 30ml, depending on the model). Format parts can be changed by hand without tools.

Control System: Equipped with a user-friendly touchscreen interface for adjusting fill volume, speed, and sealing temperature. Some models include PLC-based controls for automated fill volume adjustments and an automatic stop function to prevent accidents and reduce wastage.

Maintenance: Designed for low maintenance with easy-clean features, including a large bottom opening for access. Stainless steel construction ensures corrosion resistance and sterility.

Safety and Compliance: Complies with GMP and CE standards. Optional safety cabinets, laminar airflow, or isolators can be integrated for sterile Class 100 filling. Energy-saving features, such as automatic shut-off when idle, reduce operational costs.

Additional Features:
- Dead tray for upright ampoule collection.
- Pre-warming station for thick glass ampoules to ensure perfect sealing.
- Adjustable ampoule loading tray for handling various sizes.
- Optional servo-driven or peristaltic pump for enhanced precision and sterility.

FAQ for Double Stroke Ampoule Filling Machine

What is a Double Stroke Ampoule Filling Machine?

A Double Stroke Ampoule Filling Machine (also known as Double Head Ampoule Filler – Model AFS-2) is a fully automatic, compact monoblock machine designed for simultaneous filling and flame sealing of two glass ampoules at a time. It performs nitrogen gassing (pre, during & post-filling), volumetric piston pump filling, pre-heating, and hermetic sealing in one platform. This double-head design doubles the output compared to single-head models while maintaining high precision and sterility. It is ideal for pharmaceutical, biotech, veterinary, cosmetic, and chemical industries.

What is the production capacity and ampoule size range of the Double Stroke Ampoule Filling Machine?

The Double Stroke Ampoule Filling Machine (AFS-2) has a production capacity of up to 50 ampoules per minute (approximately 3,000 ampoules per hour). It supports ampoule sizes from 1 ml to 30 ml with a filling range of 0.5 ml to 25 ml in single dosing. Filling accuracy is ±1% (can be optimized to ±0.5%). It features quick format changeover with minimum change parts, making it suitable for medium-scale production.

What does “Double Stroke” mean in an Ampoule Filling Machine?

“Double Stroke” refers to the two-head (double head) configuration that allows two ampoules to be filled and processed simultaneously. This synchronized double-stroke mechanism, driven by a single motor, increases output efficiency without significantly increasing the machine footprint. It includes neck centering during gassing and filling, along with diving nozzles for precise, foam-free filling.

How does the Double Stroke Ampoule Filling Machine ensure sterility and sealing quality?

The machine ensures high sterility and quality through:

Nitrogen flushing before, during, and after filling to prevent oxidation and contamination.
Active pre-heating station for perfect sealing, especially with thick glass ampoules.
Precise LPG + Oxygen flame sealing with 360° ampoule rotation for uniform, leak-proof hermetic seals.
“No Ampoule – No Filling” system and dead tray for safe collection.
Contact parts made of Stainless Steel 316L and full cGMP-compliant design suitable for Class 100 environments.

What are the main benefits of using a Double Stroke Ampoule Filling Machine?

Higher output — Double-head design delivers up to 50 ampoules/minute in a compact footprint.
Excellent accuracy & minimal wastage — ±1% filling accuracy with “No Ampoule – No Fill” interlock.
Superior sterility — Multi-stage nitrogen flushing and hermetic flame sealing protect sensitive injectables.
Easy operation & maintenance — Quick changeover, full accessibility, low power consumption (0.5 HP), and user-friendly design.
Versatility — Handles 1–30 ml ampoules and suits small-to-medium batch production while meeting FDA/cGMP standards.

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