Eight Head Ampoule Filling and Sealing Machine

Q: What are the main benefits of using an Eight Head Ampoule Filling and Sealing Machine?

High-speed production — Delivers up to 12,000 ampoules/hour, ideal for large batch manufacturing. Excellent accuracy & efficiency — ±1% filling accuracy with minimal wastage and quick changeover. Superior sterility — Advanced nitrogen flushing and hermetic sealing ensure product integrity for injectables. Space & cost efficiency — Compact footprint with low maintenance and reduced labor requirements. Regulatory compliance — cGMP, FDA-compliant design with Stainless Steel 316L contact parts, suitable for high-volume sterile production.

Description

Based in Ahmedabad, Gujarat, Adinath International is well-known for being a top producer and provider of Eight Head Ampoule Filling and Sealing Machines. The company strives to provide the best technology available in the injectable SVP (small volume parenteral) market. Our equipment guarantees precise filling, the lowest breakage ratio, and excellent sealing because of the advanced manufacturing technology. The Vertical Ampoule filling and sealing machine has a greater production of about 280 to 300 ampoules per minute for 1 ml and 2 ml ampoules, and it can operate with 1 ml to 10 ml ampoules.

A single motor synchronises all of the heavy structured compact unit’s drives. Cassette magazines, smooth ampoule revolving units, pre-heating units, flow meters, variable frequency drives, vertical tray collecting, pre-warming stations, and other components are used to assemble the device. It adheres to the “No Ampoule No Filling” principle and has a minimum part change from 0.5 ml to 10 ml ampoule size. The entire unit is described in a very adaptable manner for complete accessibility and simple maintenance. Our compact cGMP model is in great demand in the filling and pharmaceutical industries.

Our internal research lab continuously develops ampoule filler and ampoule sealer for improved performance throughout the whole production process. Additionally, we offer every industry-specific customisation that the client may need.

Salient Features of Ampoule Filling and Sealing Machine

Compact cGMP model.
Higher output up to 12000 Ampoules per hour.
Machine equipped with pre-warming station.
“No Ampoule – No Filling” system.
Flow Meters for regulating flames easily.
Full accessibility allows easy maintenance.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Ampoule neck centering during gas flushing and filling operations.
Minimum change over parts from 1ml to 10ml ampoule size.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Eight Head Ampoule Filling and Sealing Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Sterilized ampoules are loaded into the slant hopper.

A synchronized star wheel delivers ampoules (in groups of eight) to a moving eccentric rack.

Ampoules move through stations for:
- Pre-Nitrogen Flushing: Inert gas to maintain sterility.
- Filling: Precise liquid dosing via chosen pump mechanism.
- Post-Nitrogen Flushing: Additional gas flush to prevent contamination.
- Preheating: Warms ampoule necks for sealing.
- Sealing: Uses LPG/oxygen for a clean, secure seal.

Filled and sealed ampoules are automatically collected in an upright position on a tray, with waste tips ejected into a separate container.

Technical Specification of Eight Head Ampoule Filling and Sealing Machine

Model Name	AFS-8
Production Speed	Up to 200 ampules/minute
Ampoule Sizes	1 ml to 20 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	2 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Eight Head Ampoule Filling and Sealing Machine

High Precision: Minimal breakage and accurate dosing for high reliability.

Low Maintenance: Quick-change parts and easy cleaning reduce operational costs.

Versatility: Handles a wide range of ampoule sizes and liquid types with customizable filling options.

Sterility: Nitrogen flushing and GMP-compliant materials ensure product safety.

Global Reach: Machines are exported to over 48 countries, with manufacturers like Adinath International offering tailored solutions.

Key Features of Eight Head Ampoule Filling and Sealing Machine

High-Speed Production:
- Capable of filling and sealing up to 12,000 ampoules per hour (approximately 80–280 ampoules per minute, depending on ampoule size and liquid viscosity). For example, it can process up to 290 ampoules/min for 1ml ampoules, 270 for 2ml, 260 for 3ml, 240 for 5ml, and 150 for 10ml.
- Ideal for medium to large-scale production lines requiring high output with minimal errors.

Filling and Sealing Mechanism:
- Filling Capacity: Handles ampoule sizes from 0.5ml to 25ml in a single dose, with precise volume control. Common models support 1ml to 10ml ampoules, with some offering flexibility up to 20ml.
- Filling Options: Equipped with multiple filling mechanisms, including:
  1. Piston Pump Filling: Ensures consistent dosing for various liquids.
  2. Servo-Driven Filling: Enhances accuracy with programmable control.
  3. Peristaltic Pump Filling: Ideal for sterile operations, minimizing contamination.
- Two-Stage Sealing Process:
  1. Preheating: Removes residual droplets to ensure clean sealing.
  2. Sealing: Uses LPG and oxygen with clippers for precise, defect-free seals.
- Nitrogen Flushing: Pre- and post-filling nitrogen purging to maintain sterility and prevent contamination.

Construction and Compliance:
- Built on a stainless steel square pipe frame with SS 316L contact parts for injectable liquids, ensuring compliance with cGMP standards. Non-contact parts are typically made of SS 304.
- GMP Compliance: Designed for sterility, with contact surfaces ensuring hygiene for injectable liquids.
- Robust Design: Heavy-duty stainless steel piping and anti-rust treatment for durability and jerk-free operation.
- Easy Maintenance: Features a large bottom opening for cleaning and quick-changeover parts to minimize downtime when switching ampoule sizes (1ml to 10ml).

Operational Efficiency:
- Slant Travel Mechanism: Ampoules move in an inclined position through filling and sealing stations, accommodating variations in neck dimensions and thicknesses.
- No Ampoule, No Fill System: Prevents liquid wastage by halting filling when no ampoule is detected.
- Neck Centering: Ensures precise alignment during filling, gas flushing, and sealing for improved accuracy.
- Automated Process: Sterilized ampoules are loaded into a slant hopper, delivered via a synchronized star wheel to an eccentric rack, and processed through pre-gassing, filling, post-gassing, preheating, and sealing stations. Filled ampoules are collected automatically without manual handling.

Advanced Features:

PLC-Based Control: Some models include a PLC with an HMI touch screen for automatic fill volume adjustments, reducing manual intervention.
Servo-Based Vertical Models: High-speed vertical fillers with 8, 12, or 16 nozzles for enhanced precision.
Pre-Warming Unit: Ensures proper heating of ampoule necks for flawless sealing, especially for thicker glass.
Gas Flow Meters: Acrylic body meters for easy flame setting (oxygen and LPG).
Optional Features:
1. Safety cabinet with doors and Class 100 laminar airflowfor sterile filling.
2. Compatibility with both open-mouthand closed-mouth (Type B and C)
3. Dead tray for upright collection of filled ampoules and waste tip collector for easy disposal.
4. CE and ISO 9001:2000 certifications for quality assurance.

FAQ for Eight Head Ampoule Filling and Sealing Machine

What is an Eight Head Ampoule Filling and Sealing Machine?

An Eight Head Ampoule Filling and Sealing Machine (Model AFS-8) is a high-speed, fully automatic monoblock system designed for simultaneous filling and flame sealing of eight glass ampoules at a time. It performs nitrogen gassing (pre, during & post-filling), volumetric piston pump filling, pre-heating, and hermetic sealing on a single compact platform. This eight-head configuration is ideal for medium to large-scale production of sterile injectables in the pharmaceutical, biotech, cosmetic, chemical, and veterinary industries.

What is the production capacity and ampoule size range of the Eight Head Ampoule Filling and Sealing Machine?

The Eight Head Ampoule Filling and Sealing Machine offers a high output of up to 200 ampoules per minute (approximately 12,000 ampoules per hour). Actual speed varies by ampoule size:

1 ml : up to 290 ampoules/min
2–5 ml : 240–270 ampoules/min
10 ml : around 150 ampoules/min

It supports ampoule sizes from 1 ml to 20 ml (filling range 0.5 ml to 25 ml in single dose) with ±1% filling accuracy. Quick format changeover with minimum change parts makes it highly flexible.

How does the Eight Head Ampoule Filling and Sealing Machine ensure sterility and sealing quality?

The machine maintains superior sterility and quality with:

Multi-stage nitrogen flushing (pre, during, and post-filling) with ampoule neck centering to prevent oxidation and contamination.
Pre-heating station followed by precise LPG + Oxygen flame sealing with 360° rotation of ampoules for uniform, leak-proof hermetic seals.
“No Ampoule – No Filling” interlock system to avoid product wastage.
Contact parts made of Stainless Steel 316L and full cGMP-compliant design suitable for Class 100 cleanroom environments.

What are the key features of the Eight Head Ampoule Filling and Sealing Machine?

Key features include:

Compact monoblock design with slant traveling (inclined) principle for gentle ampoule handling and reduced breakage.
Synchronized star wheel and eccentric rack for processing eight ampoules simultaneously.
Pre-warming unit, flow meters for accurate gas regulation, and automated collection tray.
Variable frequency drive for speed control and optional PLC + HMI for advanced operation.
Low maintenance, easy cleaning, and full accessibility with power load of 2 HP.

What are the main benefits of using an Eight Head Ampoule Filling and Sealing Machine?

High-speed production — Delivers up to 12,000 ampoules/hour, ideal for large batch manufacturing.
Excellent accuracy & efficiency — ±1% filling accuracy with minimal wastage and quick changeover.
Superior sterility — Advanced nitrogen flushing and hermetic sealing ensure product integrity for injectables.
Space & cost efficiency — Compact footprint with low maintenance and reduced labor requirements.
Regulatory compliance — cGMP, FDA-compliant design with Stainless Steel 316L contact parts, suitable for high-volume sterile production.

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