Six Head Ampoule Filling and Sealing Machine

Q: How does the Six Head Ampoule Filling and Sealing Machine work?

The machine operates on the slant (angle travel) movement principle . Pre-sterilized ampoules are loaded into the hopper and move in groups of six through synchronized stations: Pre-gassing with nitrogen flushing and neck centering Precise volumetric filling using six needles Post-gassing with nitrogen (optional) Pre-warming with low-pressure flame Flame sealing with LPG + Oxygen while ampoules rotate on rollers for a uniform hermetic seal Sealed ampoules are collected upright automatically. It includes a “No Ampoule – No Filling” system to prevent wastage and maintain accuracy.

Description

Six Head Ampoule Filling and Sealing Machine is the best choice for filling and sealing glass ampoules. ADINATH’s six-head ampoule filling and sealing machine has been utilised by numerous industries. ADINATH’s ampoule filling machines are used by the pharmaceutical, biotechnology, cosmetic, veterinary, and chemical industries. With an expanded filling capacity of 0.5 to 10 millilitres, the Adinath International Automatic six-head ampoule filling and sealing machine is compatible with a range of ampoule sizes from 1 to 10 millilitres with an open mouth. It operates on the Angle Travel principle. The machine with six heads can increase the output to 80 to 150 ampoules per minute, depending on their sizes. With a minimum of 80 ampoules each minute, this model can fill and seal up to 150 ampoules per minute. The ampoule filler machine uses the principle of slant movement of ampoules during filling and sealing to accommodate the wide range of ampoule neck diameters, thicknesses, and ovality of available ampoules. The unit has a lovely matted surface, is built on a S. S. Square pipe frame, and is fully covered in S. S. coverings. For thorough cleaning, it also features a large opening on the bottom side. The pendant-style electrical control panel is elevated from the machine for ease of use and security.

Our six-head filler and sealer is made from sturdy, heavy-duty stainless steel components. Adinath International, a respectable manufacturer of pharmaceutical equipment, started the development of ampoule filling machines, which are CE approved and have DUNS numbers. Ampoule filling and sealing equipment are exported to several international countries as needed. Our research engineers keep adding new functions to the equipment over time. We also provide them modification according to our clients’ requirements.

Salient Features of Ampoule Filling and Sealing Machine

Compact cGMP model.
Higher output up to 9000 Ampoules per hour.
Machine equipped with pre-warming station.
“No Ampoule – No Filling” system.
Flow Meters for regulating flames easily.
Full accessibility allows easy maintenance.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Ampoule neck centering during gas flushing and filling operations.
Minimum change over parts from 1ml to 10ml ampoule size.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Six Head Ampoule Filling and Sealing Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect six ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Loading: Sterilized ampoules are loaded into the slant hopper and fed onto a wire mesh conveyor or receiving rack via a star wheel.

Pre-Gassing: Nitrogen is flushed into ampoules to create an inert environment.

Filling: Six needles dispense a preset volume of liquid (or powder) with high accuracy, aided by neck centering to prevent spillage.

Post-Gassing: A second nitrogen flush ensures sterility post-filling.

Pre-Warming: A low-pressure flame warms ampoules to prepare for sealing, removing residual droplets.

Sealing: Rollers rotate ampoules while a high-pressure flame (oxygen + LPG) seals them, ensuring airtight closure.

Collection: Sealed ampoules are automatically collected in an upright position on a tray for further processing (e.g., labeling or inspection).

Technical Specification of Six Head Ampoule Filling and Sealing Machine

Model Name	AFS-6
Production Speed	Up to 150 ampules/minute
Ampoule Sizes	1 ml to 20 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	2 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	2000mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Six Head Ampoule Filling and Sealing Machine

High output with minimal labor due to automation.

Precise filling and sealing, reducing product wastage.

Robust, hygienic design compliant with cGMP standards.

Flexible for various ampoule sizes and product types.

Low maintenance with easy cleaning and tool-less changeovers.

Key Features of Six Head Ampoule Filling and Sealing Machine

Six Filling Heads: Equipped with six precision needles for simultaneous filling, enabling higher throughput compared to single or dual-head machines. Output ranges from 80 to 280 ampoules per minute, depending on ampoule size.

Construction: Built with a robust stainless steel square pipe frame and matt-finished coverings, meeting cGMP standards for hygiene and durability. A large bottom opening facilitates easy cleaning and maintenance.

Filling Mechanism: Utilizes volumetric piston pumps or optional peristaltic pumps for accurate dosing (0.5 ml to 25 ml). Features a “No Ampoule, No Filling” system to minimize wastage by ensuring liquid is dispensed only when an ampoule is present.

Nitrogen Flushing: Includes pre- and post-nitrogen purging stations to flush inert gas, reducing oxidation and contamination, ensuring product sterility.

Sealing Process: Incorporates a pre-warming station with a low-pressure flame to prepare ampoules for sealing, followed by a sealing unit using oxygen and LPG (propane). Specially designed rollers rotate ampoules for uniform, 360-degree sealing.

Automation and Control: Features a pendant-type electrical control panel for ease of operation and safety. PLC systems allow real-time parameter adjustments and error monitoring. Flow meters regulate flames, and an efficient cooling system prevents overheating.

Ampoule Handling: Ampoules are loaded via a slant hopper and transferred by a synchronized star wheel to an eccentric rack, moving in groups of six. The rack’s slant travel ensures precise positioning during pre-gassing, filling, post-gassing, pre-heating, and sealing. Filled and sealed ampoules are collected upright in a tray for further processing.

Versatility: Suitable for open-mouth and closed-mouth ampoules (Type B and C). Can handle liquids, powders, or pellets, with applications in pharmaceuticals, cosmetics, and agrochemicals.

Output Capacity: Typically achieves 6,000 to 12,000 ampoules per hour, depending on size and configuration, making it ideal for medium to large-scale production.

Safety and Efficiency: Includes safety valves, pressure reducers, and a stainless steel hood to channel fumes during sealing. Minimal changeover time for different ampoule sizes (1 ml to 10 ml) with tool-less format changes.

FAQ for Six Head Ampoule Filling and Sealing Machine

What is a Six Head Ampoule Filling and Sealing Machine?

A Six Head Ampoule Filling and Sealing Machine (Model AFS-6) is a high-speed automatic equipment designed for filling and hermetically sealing glass ampoules with sterile liquid pharmaceuticals. It features six filling heads that work simultaneously, making it suitable for medium to large-scale production of injectables, vaccines, antibiotics, serums, and biotech products. The machine ensures sterility through nitrogen flushing and precise flame sealing while complying with cGMP standards.

What is the production capacity and ampoule size range of the Six Head Ampoule Filling Machine?

The Six Head Ampoule Filling and Sealing Machine offers a high output of 80 to 150 ampoules per minute (up to 9,000 ampoules per hour depending on size). It handles 1 ml to 20 ml glass ampoules with a filling range of 0.5 ml to 25 ml (typically 0.5 ml to 10 ml in single dose). Minimum changeover parts are required for sizes from 1 ml to 10 ml, allowing fast and easy format changes.

How does the Six Head Ampoule Filling and Sealing Machine work?

The machine operates on the slant (angle travel) movement principle. Pre-sterilized ampoules are loaded into the hopper and move in groups of six through synchronized stations:

Pre-gassing with nitrogen flushing and neck centering
Precise volumetric filling using six needles
Post-gassing with nitrogen (optional)
Pre-warming with low-pressure flame
Flame sealing with LPG + Oxygen while ampoules rotate on rollers for a uniform hermetic seal

Sealed ampoules are collected upright automatically. It includes a “No Ampoule – No Filling” system to prevent wastage and maintain accuracy.

What are the key features and benefits of the Six Head Ampoule Filling and Sealing Machine?

Key features include:

Six filling heads for higher production speed
“No Ampoule – No Filling” system with neck centering
Pre & post nitrogen flushing facility
Pre-warming station and flow meters for easy flame regulation
High filling accuracy of ±1%
Contact parts in SS 316L and non-contact parts in SS 304
Compact cGMP model with full accessibility and easy cleaning
Low maintenance and minimum changeover time

Benefits: It delivers high output with minimal labor, reduces product wastage, ensures excellent sterility, and is ideal for scalable injectable manufacturing in pharmaceutical and biotech industries.

What are the technical specifications and compliance standards for the Six Head Ampoule Filling Machine?

The machine requires LPG & Oxygen for sealing and supports pre & post nitrogen flushing. Power load is 2 H.P. (230 Volts, Single Phase, 50 Hz – customizable). It is fully cGMP compliant with easy-to-clean design (large bottom aperture) and can integrate with laminar airflow for sterile operation. Maintenance is straightforward due to full accessibility. We provide detailed manuals, operator training, and reliable after-sales support with spare parts to minimize downtime.

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