Vial Powder Filling & Plugging Machine

Description

Vial Powder Filling & Plugging Machine was designed to facilitate the filling of injectable glass vials with liquid. Conveyor belts, turntables, pre-gassing, filling, and post-gassing components make up the machine’s main components. The 316L quality stainless steel used to make this plugging and capping machine satisfies GMP requirements and guarantees the highest long-term return on investment. Easy access is made possible by the small panel and synthetic rubber tubes.

The self-picking roller-based rubber stoppering technology of the Automatic High Speed Injectable Dry Powder Filling with Rubber Stoppering Machine is entirely mechanical. This machine can tolerate extended working hours and has a very robust build. A vacuum and air pressure-based powder wheel with a manual fill weight adjustment is used for filling. From monolithic mechanical machines to our cutting-edge servo-driven centralised piston adjustment aspetic vial powder filling machine, which is intended to fill microdoses of sterile powder into glass vials and seal them with rubber stoppers, we have developed a variety of aseptic (sterile) powder filling and rubber stoppering machines.

We are a top producer of Automatic Dry Injectable Powder Filling Machine, Vial Filler, High Speed Injectable Powder Filling Machine, Automatic Vial Powder Filling Machine, Dry Syrup Powder Filling Machine, High Speed Dry Syrup Powder Filling Machine, Vial Filling and Stoppering Machine, Vial Filling and Plugging Machine, Vial Dry Powder Filling Machine, Powder Injection Vial Filling Machine, Sterile Powder Filler Rubber Stoppering Machine, etc. automated filling systems, sterile and aseptic processing, and pharmaceutical manufacturing.

  • Vial Infeed: Empty, sterilized vials are loaded onto an infeed turntable or slat conveyor and transported to the filling station, where proximity sensors detect and position them under nozzles.

 

  • Powder Filling: Agitated powder from the hopper is metered into the powder wheel. Sequential air pulses dispense pre-set volumes into each vial.

 

  • Vial Separation and Transfer: Filled vials are separated on the conveyor and moved to the bunging station.

 

  • Bunging/Stoppering: Rubber bungs are fed from a vibratory bowl through a chute and pressed into the vial necks using pneumatic cylinders.

 

  • Outfeed: Completed vials exit via an outfeed turntable for downstream processes like capping, sealing, or labeling.

Working Principle of Vial Powder Filling & Plugging Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Vial Powder Filling & Plugging Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Applications of Vial Powder Filling Machine

Benefits of Vial Powder Filling Machine

High Filling Accuracy for Powders

Higher Production Output

Built-in Rubber Plugging (Stoppering)

Excellent Sterility & cGMP Compliance

Minimal Powder Wastage

Consistent Powder Flow & Dosing

Key Features of Vial Powder Filling & Plugging Machine

  • Filling Mechanism: Utilizes a vacuum-driven powder wheel with servo motors for precise dosing. Powder is stored in a hopper with mechanical agitators to maintain uniform bulk density. Compressed air or nitrogen flushes the powder into vials through nozzles, achieving filling accuracy of ±2% (depending on powder characteristics).

 

  • Bunging/Stoppering System: Integrated rubber stopper delivery via a vibrating bowl and chute. Supports full or half bunging for lyophilized products, with pneumatic pressing for secure placement in a sterile environment.

 

  • Production Capacity: Outputs range from 30 to 250 vials per minute (VPM), scalable with models featuring single or double powder wheels.

 

  • Safety and Controls: Includes no-vial/no-stopper detection to halt operations, clutch systems for vial breakage prevention, and PLC-based HMI for speed adjustment and digital counting. Optional laminar airflow for Class 100 sterile filling, IQ/OQ validation, and rejection systems.

 

  • Construction: Contact parts made from SS 316L for corrosion resistance; framework in SS 304. Tool-less adjustments for blades and easy changeovers.

FAQ for Vial Powder Filling & Plugging Machine

The machine is available in two main models:

  • APF 12S (Single Track): Up to 100 vials per minute
  • APF 12D (Double Track): Up to 200 vials per minute

It supports vial sizes from 5 ml to 250 ml and fill volumes from 50 mg to 10 grams per vial.

The machine offers a filling accuracy of ±2% to ±3% (depending on powder bulk density and uniformity). Accuracy is achieved through precise piston depth adjustment in the powder wheel ports and consistent vacuum + compressed air/nitrogen dosing.

The machine uses an eight-port powder wheel with vacuum suction. Sterile powder from an agitated hopper is drawn into the ports. Excess powder is removed by a doctor blade for uniform density. Compressed air (or nitrogen) then flushes the exact dose into the vial. This is followed by immediate rubber stoppering to maintain sterility.

Key anti-wastage features include:

  • “No Vial – No Filling” system
  • Precise vacuum and doctor blade control
  • Safety clutch to prevent vial breakage
  • Agitators for uniform powder density These features ensure minimal spillage and consistent dosing of expensive sterile powders.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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