

Vial Powder Filling and Stoppering Machine, also known as a vial filler or Injectable Powder Filling Machine, is a highly specialized system designed to accurately fill and rubber-stopper injectable powder vials used in pharmaceutical production. Adinath, a trusted name in pharmaceutical machinery, offers a comprehensive range of vial filling machine models engineered to meet the exacting demands of the pharmaceutical sector. These machines combine robust construction, user-friendly operation, and full cGMP compliance, making them a preferred choice for manufacturers seeking reliability and efficiency.
Engineered for extended working hours, our vial powder filling machines feature a heavy-duty, robust build with a stainless steel frame and all product-contact parts made from high-grade SS316 material. This ensures maximum durability, easy cleaning, and compliance with stringent sterility requirements. The machine incorporates built-in turntables at both infeed and outfeed stations, each powered by separate motors to perfectly synchronize vial movement and prevent jams or misalignment.
The filling process begins when dry powder is loaded into the upper filling hopper. The machine’s intelligent design utilizes a vacuum and air pressure-based powder wheel (available in single head, single track, eight-port configurations) to ensure precise dosing through a dosing disc. This sophisticated system delivers uniform and consistent powder filling, significantly reducing product waste while maximizing output and accuracy. Available in both single and double powder wheel varieties, these machines support production outputs ranging from 60 to 200 VPM (vials per minute). For even greater precision, servo-driven powder fillers allow centralized and accurate powder wheel positioning. A specially designed vacuum-driven powder wheel further enhances filling consistency, particularly important for micro-dosing applications.
After filling, vials are smoothly transferred to the stoppering station without interrupting workflow. The machine features an advanced online vibrator-style rubber stoppering system that inserts stoppers continuously at synchronized speeds. This integrated filling-to-stoppering transition ensures a streamlined, high-efficiency production process.
To provide end-to-end solutions, we offer fully automated vial powder filling lines that integrate our vial filling and stoppering machine with vial cap sealing machines and vial labeling machines. This complete system delivers unmatched productivity and compliance for modern pharmaceutical facilities.
With deep expertise in sterile powder processing equipment, Adinath delivers vial powder filling and stoppering machines that combine advanced technology, mechanical reliability, and regulatory compliance. Our machines are designed for minimal downtime, easy maintenance, and consistent high-quality output — critical factors for producing safe and effective injectable powder products. Whether you need a compact single-track system or a high-speed double-track solution, our automatic vial powder filling machines represent a smart investment backed by manufacturing excellence and dedicated technical support.
We provide multiple configurations to suit diverse production needs:
Each variant is available with customization options tailored to specific customer requirements, ensuring optimal performance regardless of batch size or vial specifications.
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
A Vial Powder Filling & Stoppering Machine is a compact, automatic monoblock system designed for aseptic filling of sterile injectable powders (such as antibiotics) into glass vials followed by immediate rubber stoppering. It uses a vacuum-based powder wheel system and is cGMP compliant, making it ideal for pharmaceutical and biotech production with minimal human intervention.
The machine offers a filling accuracy of ±2% to ±3% (depending on powder bulk density and uniformity). Accuracy is achieved by adjusting the piston depth in the powder wheel ports along with consistent vacuum suction and compressed air/nitrogen flushing.
Sterile powder from an agitated hopper is drawn into the eight-port powder wheel by vacuum. Excess powder is removed by a doctor blade for uniform density. Compressed air (or nitrogen) then flushes the precise dose into the vial. Filled vials immediately move to the built-in vibrator-type rubber stoppering station for secure stopper placement, maintaining sterility throughout the process.
The machine can be customized with servo-driven systems, single/double powder wheel configurations, PLC with HMI, inbuilt laminar airflow, in-process weight checking, nitrogen flushing, and different change parts. It can also be integrated into a complete line with vial washing, depyrogenation tunnel, and capping machines. IQ/OQ documentation is provided for validation.
Key features include the “No Vial – No Filling” system, precise doctor blade control, safety clutch to prevent vial breakage, mechanical agitators for uniform powder density, and multiple dosing options. These features significantly reduce expensive sterile powder wastage and spillage.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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