Automatic Ampoule Vial Washing Machine

Q: What is the output capacity and size range of the Automatic Ampoule Vial Washing Machine?

The machine is available in two main models: AVRW-120 : Up to 100 ampoules/vials per minute AVRW-240 (High Speed): Up to 200 ampoules/vials per minute Supported sizes : Ampoules: 1 ml to 10 ml (diameter 9 mm to 21.5 mm, height 60 mm to 140 mm) Vials: 1 ml to 20 ml (with appropriate change parts, same diameter and height range) Quick changeover is possible with interchangeable parts, and speed is adjustable via a digital indicator.

Q: What washing stages and key features does the Automatic Ampoule Vial Washing Machine offer?

The machine features 6 internal washing stations and 3 external washing stations , with 36 cleaning needles (6 per station). Typical washing sequence (adjustable): Recycled Water / WFI → Compressed Air DM / Purified Water → Compressed Air Final WFI → Final Compressed Air Key features include: Automatic infeed/outfeed with 15 cassettes of grippers (2 grippers each) Inverted neck-down washing for thorough internal cleaning All contact parts in AISI 316L Stainless Steel 3 tanks & 3 pumps (25 liters each) with recirculation to save WFI Digital speed indicator, container counter, and optional PLC + HMI No-vial-no-wash system (optional), safety cabinet, and 21 CFR Part 11 compliance (optional)

Description

The purpose of a rotating Automatic Ampoule Vial Washing Machine is to continuously rotate while cleaning the inside and outside of vials. Grippers are used to hold vials and invert their position so that servo-driven nozzles can move vertically to cleanse the inside of the vials. It features six dome-covered washing stations that offer three different types of internal water washes, including recycled water wash, purified water wash, and WFI wash, as well as three air washes. One PLC-controlled water and air wash is used to clean external surfaces. The machine’s small design guarantees that the washing process is clearly seen.

One of the best products available is the Automatic Ampoule Vial Washing Machine, which has several amazing characteristics. This long-lasting machine is ideal for use in pharmaceutical manufacturing facilities because it is made of premium stainless steel. This machine’s automatic grade system is intended to increase productivity and optimise your production process. The machine is capable of handling even the most difficult duties since it runs at a frequency of 50–60 Hertz (HZ) and a voltage of 220–440 Volt (v). This machine has a straightforward interface that lets you get started right away, and despite its amazing capabilities, it is surprisingly simple to use.

We have two different models in this machine. The AVRW-120 Automatic Ampoule Washing Machine could only generate 100 ampoules per minute, however the AVRW-240 High Speed Ampoule Washing Machine could generate up to 200 ampoules per minute. The automatic ampoule and vial washer or the high-speed ampoule and vial washer can be used to clean one millilitre to twenty millilitre ampoules and vials. We provide extended support for ampoule vial combi washing machine validation and replacement parts.

Salient Features of Ampoule Vial Washing Machine

Complete cGMP model.
Production output capacity up to 200 ampoules per minute.
All contact parts with the internal surface of Container and the wash media are made from AISI 316L Stainless Steel.
Non-contact parts are made from engineering plastic, AISI SS 304 materials.
All finishes, welding joints are processed, treated & equipment selected in accordance with cGMP standards.
Machine provides 3 water washes & 3 Air washes.
Complete flexibility with user for washing cycle.
18 Jets for 6 internal washing zones.
15 Cassette of Grippers each having 2 Grippers.
Suitable for 1ml to 10ml ampoules.

Washing sequence can be adjusted as per customer’s requirements.
3 Pumps and 3 Tanks of 25 liters each. (Optional)
Each washing zone with independent circuit to avoid contamination.
Automatic Infeed and Exit of containers.
Machine is equipped with PLC system & printing facility with passwords. (Optional)
Container unit counter with display in the control panel
Machine can use as a sole machine or inline.
Digital speed indicator for current output
IQ/OQ/DQ validation documentation can be provided.
Programming and software validation as per 21 CFR Part 11 can be done on demand.

Working Principle of Automatic Ampoule Vial Washing Machine

Ampoules and vials feed from the Infeed tray are received on an Infeed Feed worm then moves on Infeed starwheel. The Grippers picks up the Ampoule from Infeed Star Wheel and invert it in neck down position over washing needles and move along with the needle bar for Washing. Ampoules traveling in neck down position above washing needles and moves along with the Needle bar ensures maximum time for washing once the needle enter in the Ampoule neck. Machine having six different washing stations each of 6 needles for optimum Washing and the sequence can be adjusted as per requirements. Washer also having external wash for optimum washing of ampoules and vials.

On completion of a cycle, washed Ampoules and vials are again inverted to neck upward position and feed to output star wheel. Washed Ampoules received from output starwheel can be collected on Output Tray or can be pushed to tunnel. A separate pumping station (optional) gives the right quantum of water at the desired pressure. In the absent of separate pumping station, we can provide the re-circulation & siliconization system on request.

INTERNAL CLEANING:

The AVRW is equipped with 6 internal cleaning stations and each station has 6 cleaning needles making up a total of 36 cleaning needles. Each cleaning station is supplied via a pipe connected to the cleaning media-making washing area. This not only reduces the risk of particle generation, but also simplifies maintenance and cleaning efforts while saving time.

EXTERNAL CLEANING

The 3 external cleaning stations mounted in a stationary position above the ampoule can be easily adjusted for a specific height, angle and lateral position. Each cleaning station receives cleaning media-making through a pipe connected to the cleaning media-making washing area.

CLEANING MEDIA PRINCIPAL:

WFI, Purified water and air cleaning station are synchronized with the ampoule by reciprocating motion. Design is such that these media are put to use only when needles motion in forward direction. WFI consumption is further reduced by collecting the WFI in re-circulating water tank to be used later on in the pre-washing station.

Technical Specification of Ampoule Vial Washing Machine

Model	AVRW 120	AVRW 240
Production Output	Up to 100 per minute	Up to 200 per minute
Ampoule Diameter	9mm to 21.5mm	9mm to 21.5mm
Ampoule Height	60mm to 140mm	60mm to 140mm
Power Load	4 H.P.	5.5 H.P.
Power Voltage	440 Volts, 3 Phase 50 Hertz, 4 wire system	440 Volts, 3 Phase 50 Hertz, 4 wire system.
Optional Accessories	Programmable Logic Control (System) with HMI Safety Cabinet with doors	Programmable Logic Control (System) with HMI Safety Cabinet with doors
Utility	Air – 20 CFM Water – 200 to 500 liters per hour depend upon ampoule size.	Air – 20 CFM Water – 200 to 500 liters per hour depend upon ampoule size.
Water Tank & Pump	3 nos. each with 25 liters Capacity & Centrifugal pump	3 nos. each with 25 liters Capacity & Centrifugal pump
Overall Dimension:	2050mm (L) X 2000mm (W) X 1210mm (H) approx.	2450mm (L) X 2000mm (W) X 1300mm (H) approx.
Net Weight	700 kgs. approx.	900 kgs. approx.
Gross Weight	1000 kgs. approx.	1300 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Washing Machine

Ampoule Vial Washing Machine

Automatic Ampoule Washer

Automatic Rotary Ampoule Washing Machine

Automatic External Ampoule Washing Machine

High Speed Ampoule Washing Machine

Lab Scale Ampoule Washing Machine

Multijet Ampoule Washing Machine

Linear Ampoule Washing Machine

Applications of Ampoule Vial Washing Machine

Washing Cycle of Automatic Ampoule Vial Washing Machine

1^st wash	Recycled Water (WFI)
2^nd wash	Compressed Air
3^rd wash	DM Water
4^th wash	Compressed Air
5^th wash	Water for Injection (WFI)
6^th wash	Compressed Air

Advantages of Automatic Ampoule Vial Washing Machine

High-Speed Production with Consistent Quality

Superior Internal & External Cleaning with Multi-Station Jets

Minimal Contact Design – Reduced Contamination Risk

Full cGMP Compliance & Easy Regulatory Validation

Key Features of Automatic Ampoule Vial Washing Machine

Construction: Made of AISI 316L stainless steel for contact parts and AISI 304 or FDA-approved engineering plastics for non-contact parts, ensuring durability and hygiene.

Gripper System: A specialized gripper holds containers by the neck, inverts them for washing, and releases them in a vertical position post-washing, minimizing contamination.

Washing Process: Typically includes 3 water washes (e.g., recycled water, purified water, Water for Injection – WFI) and 3 air washes for internal and external cleaning. Washing sequences are customizable.

Capacity: Models like AVRW-120 (up to 100 ampoules/vials per minute) and AVRW-240 (up to 200 ampoules/vials per minute) cater to different production needs.

Operation: Fully automatic with PLC control, optional printing facilities, and safety features like automatic stop if the acrylic cover is lifted. No-vial-no-wash systems reduce water and air wastage.

Cleaning Efficiency: Uses pressurized jets via multiple washing stations (e.g., 6 stations with 6 needles each) for thorough internal and external cleaning. WFI consumption is optimized via recirculation tanks.

Flexibility: Handles various container sizes (1ml to 20ml ampoules, 2ml to 100ml vials) with change parts. External washing stations are adjustable for precise cleaning.

Compliance: Designed to meet cGMP, GAMP, and 21 CFR Part 11 standards, with IQ/OQ/DQ validation documentation available.

FAQ for Automatic Ampoule Vial Washing Machine

What is an Automatic Ampoule Vial Washing Machine?

An Automatic Ampoule Vial Washing Machine is a rotary-type, high-performance cGMP-compliant equipment designed to clean both glass ampoules and vials internally and externally. It uses a gripper system that inverts containers neck-down and employs multiple high-pressure jets of recycled water, purified/DM water, Water for Injection (WFI), and compressed air to remove dust, particles, and contaminants. This makes the containers ready for sterilization and filling in sterile injectable production lines. The machine is ideal for pharmaceutical manufacturers who need flexibility to process both ampoules and vials on the same line.

What are the main applications of the Automatic Ampoule Vial Washing Machine?

This machine is primarily used in the pharmaceutical industry for washing glass ampoules and vials before filling injectable drugs, vaccines, biologics, and sterile solutions. It is also suitable for:

Biotechnology products
Veterinary medicines
Cosmetic injectables and serums
Chemical industry applications requiring high cleanliness

It supports both standalone operation and inline integration with a sterilizing tunnel and filling machine.

What is the output capacity and size range of the Automatic Ampoule Vial Washing Machine?

The machine is available in two main models:

AVRW-120: Up to 100 ampoules/vials per minute
AVRW-240 (High Speed): Up to 200 ampoules/vials per minute

Supported sizes:

Ampoules: 1 ml to 10 ml (diameter 9 mm to 21.5 mm, height 60 mm to 140 mm)
Vials: 1 ml to 20 ml (with appropriate change parts, same diameter and height range)

Quick changeover is possible with interchangeable parts, and speed is adjustable via a digital indicator.

What washing stages and key features does the Automatic Ampoule Vial Washing Machine offer?

The machine features 6 internal washing stations and 3 external washing stations, with 36 cleaning needles (6 per station). Typical washing sequence (adjustable):

Recycled Water / WFI → Compressed Air
DM / Purified Water → Compressed Air
Final WFI → Final Compressed Air

Key features include:

Automatic infeed/outfeed with 15 cassettes of grippers (2 grippers each)
Inverted neck-down washing for thorough internal cleaning
All contact parts in AISI 316L Stainless Steel
3 tanks & 3 pumps (25 liters each) with recirculation to save WFI
Digital speed indicator, container counter, and optional PLC + HMI
No-vial-no-wash system (optional), safety cabinet, and 21 CFR Part 11 compliance (optional)

How does the Automatic Ampoule Vial Washing Machine ensure compliance and product safety?

Built as a complete cGMP model, the machine uses AISI 316L Stainless Steel for all product-contact parts to prevent contamination. Independent washing circuits, inverted washing, and minimal container contact minimize cross-contamination risks. It comes with IQ/OQ/DQ validation documentation, and optional features include PLC with HMI, password protection, printing facility, and 21 CFR Part 11 compliant software. This ensures it meets stringent regulatory standards for sterile injectable manufacturing while offering low water consumption and easy cleanroom integration.

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