Automatic Vial Powder Filling Machine

The machine is available in two models:

• APF 12S: Up to 100 vials per minute
• APF 12D: Up to 200 vials per minute

It handles vial sizes from 5 ml to 250 ml and fill volumes from 50 mg to 10 grams. The standard volumetric filling accuracy is ±2–3%, depending on powder characteristics, density, and environmental conditions. Advanced servo-controlled options can achieve even higher precision. The “No Vial – No Filling” system prevents costly powder wastage.

This machine is primarily designed for sterile, free-flowing to slightly cohesive injectable powders used in antibiotics and other parenteral formulations. It works with round glass vials (5 ml to 250 ml). The powder wheel system with vacuum and compressed air (or nitrogen) ensures consistent dosing even with powders that require uniform density. Changeable parts allow flexibility for different dose ranges and vial sizes.

Yes. All product contact parts are made from FDA-approved materials or SS 316L and are easily removable for autoclaving/sterilization. The machine is built as a compact cGMP model and supports integration with Class 100 laminar airflow, RABS, or isolators. It can be supplied with IQ/OQ validation documentation and meets requirements of FDA, EU-GMP, and WHO guidelines for aseptic processing of sterile powders.

Key features include:

• “No Vial, No Filling” system
• Built-in online rubber stoppering unit
• Safety clutch to prevent vial breakage
• Variable speed control via AC frequency drive
• Individual drives for filling and stoppering
• Digital production counter
• Overload and jamming protection

Optional accessories include inbuilt laminar airflow, servo motors, in-process weight checking with rejection, multiple dosing systems, and split-filling for different powders. Contact parts can be customized as per specific requirements.