Vial Filling and Bunging Machine

Description

An effective device for filling glass vials with liquid inejectables is a Vial Filling and Bunging Machine. Rubber stoppers are inserted by the vial filler machine after the vial has been filled with liquid. Piston pumps and peristaltic pumps are used in vial liquid filling machines to help achieve the highest level of filling accuracy. For round vials, however, automatic vial filling machines are the recommended option. In order to prevent contamination, it further stipulates that rubber stoppers must be positioned atop the containers. As one of the top producers of vial filling machines, we guarantee precise operations with little waste or spillage. The vial liquid filling machine can handle a lot of vials per hour due to its excellent workability. It has an accuracy of +/- 1% when fitting a rubber stopper with a 20 mm diameter. The type of liquid to be filled and the fill volume in each vial determine the injectable liquid filler output rate. An eight-head vial filling machine can get 120 fills per minute, whereas a four-head vial filling machine can achieve 60 fills per minute. A two-head vial filling machine can produce 20 fills per minute. The vial filling machine, also known as a vial filler, has a fill capacity of 2 ml to 250 ml in a single machine with a single dosing capability and requires a 2 H.P. electric supply.

The main structure of the Automatic Vial Filling and Rubber Stoppering Machine is protected by a safety acrylic cover made of stainless steel, laminar air flow, an in-feed turntable, a peristaltic pump filling machine, a Delrin Slate conveyor, an outfeed turn table, a vibrator bowl and rubber stopper chute, pneumatic parts, an electrical panel, an AC drive, a PLC, and an HMI.

Salient Features of Vial Filling and Bunging Machine

No cross contamination.
Suitable for the filling Volume of 2ml to 250ml.
Piston pump/Peristaltic pump aseptic filling.
Filling with accuracy of ±0.5-1%.
Easy to validate filling system for small/large batch production.
All Contact Parts Made from S.S 316L & framework by S.S. 304.
Variable A.C. frequency drive for speed adjustment.
Digital Vial Counter for counting production output.
In-feed Turn Table/ Unscrambler for automatic feeding of objects.
On-line Mechanism.
“No Vial – No Filling” system.
“No Vial – Machine Stop” system.
IQ/OQ documentation can be provided to comply vial filling machine validation process.
PLC with Graphical User Interface. (Optional)
PRIME is a distinctive feature that allows you to quickly suck filling material from the storage tank to the nozzle end. This feature is also beneficial for cleaning the filling line (silicon tubing) and filling the peristaltic pump in both directions.
PLC alarms for “No Vial, Machine Stop” and “No Vial, No Bung.”
For daily track reports and planning, a password-protected production counter is provided.
The errors can be recognized on the touch screen HMI of the PLC and readily attended to.

The machine can use the PRIME function for all peristaltic pumps together or for individual peristaltic pump.
Filling is done with a specifically built filling peristaltic pump which has CIP and SIP ability.
Individual pumps may be calibrated and adjusted for the desired volume using a simple PLC.
Because of a particularly built peristaltic pump with suck back capability, oil-based materials can also be run without dripping.
Each filling head may operate independently, allowing the machine to operate constantly without sacrificing significant production.
Bung orientation bowl and discharge chute with built-in vibrator. For use with wet bungs, we offer bung orienter bowl and chute with Teflon coating.
Bungs are held in a specifically designed vacuum bung hold disc, which then discharges the bung evenly onto the vial. The bung pressing roller evenly presses the bungs.
Half stoppering can be done with the same Rubber bunging machine assembly.
Each filling head may operate independently, allowing the machine to operate constantly without sacrificing significant production.
For varied sizes of vials and filling volumes, no change parts are necessary.
Because mechanical parts like syringe sets, Teflon seals, gears, and chains are rarely used, there is relatively little product variation over time.
PLC with simple controls for volume and speed adjustments.
The entire assembly can be adjusted upwards and lower to accommodate different heights of vials.
To avoid the negative effects of the electric supply, the machine is supplied with an isolated power source.
Well known mechanical components such as FESTO/Janatics pneumatics and CE approved electrical/electronic components such as Bonfiglioli/Crompton AC motors, Allen Bradley drives, PLC & HMI Touch screen, Sensors, MCB’s, relays, and other components.

Working Principle of Vial Filling and Bunging Machine

The incoming dry vials (sterilized and siliconised) are fed through the in-feed turn table and suitably guided on the moving Stainless Steel slat conveyor belt at the required speed of the correct placement below filling unit.

The filling unit consists syringes & nozzles. Syringes are made of Stainless Steel 316L material for cGMP compliance. Vials stop below filling unit with centering of filling nozzles, during stoppage nozzles discharge pre determined liquid into vials. Duly filled vials delivered on stoppering unit which is mounted on same platform.

Stoppering Unit consist Bowl and Chute designed for desired stopper / bung size. Stoppers are stored in vibratory bowl and delivered to the vial through delivery chute. Vibratory bowl is equipped with special vibrator motor. Stoppers travel in vibratory bowl support guide through vibration. There is arrangement in the bowl in which wrong position stopper get rejected in travelling and only correct position of stopper get into chute. Further stoppers hold at delivery point of chute through spring which collected one by one by vial in traveling below the chute. Further there is one Stainless Steel 304 roller installed to press the stoppers. Vial transfer below the wheel in which get stoppered.

Duly stoppered vials further move on conveyor & collected on out feed turn table (optional) or on to conveyor of vial aluminum cap sealing machine for cap sealing operations.

Vial Loading: Empty, sterilized vials are fed via the infeed turntable onto a conveyor.

Filling Process: Vials move to the filling station, where nozzles descend to inject the exact volume of liquid. The synchronized motion filling system allows nozzles to track vials without stopping the line, enhancing speed.

Stoppering Process: Filled vials transfer to the stoppering station, where a vibrating bowl dispenses oriented rubber stoppers into a chute. Vials are held by a rotating star wheel, picking up stoppers that are then pressed down by rollers.

Output: Stoppered vials exit via the outfeed turntable for further processes like capping or labeling.

Technical Specification of Vial Filling and Bunging Machine

Model	ALVF-40	ALVF-80	ALVF-120	ALVF – 250
Filling Heads	Two	Four	Eight	Twelve
Production Rate	Up to 40 Vials/Minute	Up to 80 Vials/Minute	Up to 150 Vials/Minute	Up to 250 Vials/Minute
Input Specification
Vial Diameter	15mm to 70mm	15mm to 70mm	15mm to 70mm	15mm to 70mm
Vial Height	25mm to 140mm	25mm to 140mm	25mm to 140mm	25mm to 140mm

Filling Precision	±1%	±1%	±1%	±1%
Power Required	1 H.P.	1.5 H.P.	2 H.P.	2 H.P.
Electrical Characteristics	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz
Overall Dimension	2050mm (L) x 850mm (W) x 1700mm (H)	2200mm (L) x 850mm (W) x 1700mm (H)	3000mm (L) x 945mm (W) x 1700mm (H)	3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Automatic Vial Filling Machine

High Speed Vial Filling Machine

Vial Liquid Filling Machine

Vial Powder Filling Machine

Automatic Vial Filling and Rubber Stoppering Machine

Lab Scale Vial Filling Stoppering & Cap Sealing Machine

Injectable Vial Powder Filling & Stoppering Machine

Peristaltic Pump based Vial Filling Machine

Applications of Vial Filling Machine

Benefits of Vial Filling and Bunging Machine

High Production Efficiency and Speed

Superior Filling Accuracy and Reduced Product Waste

Enhanced Sterility and Product Safety

Easy Operation, Quick Changeover, and Low Maintenance

Labor Savings, Cost Efficiency, and Seamless Line Integration

Key Components of Vial Filling and Bunging Machine

Infeed and Outfeed Systems: Built-in turntables with individual drives for smooth vial entry and exit, often including a Delrin slat conveyor to prevent sticking and ensure consistent movement.

Filling Station: Equipped with multiple heads (e.g., 2, 4, 8, or 12) for simultaneous filling. Nozzles move vertically via cam mechanisms for precise dosing, with options for nitrogen flushing before and after filling to minimize oxidation. A “No Vial, No Fill” system prevents liquid wastage.

Stoppering Unit: Features a vibrating bowl and Teflon-coated chute for orienting and feeding rubber stoppers. Vacuumetric or pneumatic systems pick and press stoppers uniformly using spring-loaded rollers, supporting both full and half-stoppering.

Safety and Construction: All liquid-contact parts are made of stainless steel (SS 316L) for easy sterilization and autoclaving. The machine includes acrylic safety covers, laminar airflow for cleanroom compatibility, and PLC/HMI controls for automation.

Drive System: Powered by high-quality gear motors and AC drives for vibration-free operation, with minimal oil leakage.

FAQ for Vial Filling and Bunging Machine

What is a Vial Filling and Bunging Machine?

A Vial Filling and Bunging Machine is a compact automatic monoblock system designed for precise filling of sterile liquids or powders into glass vials followed by rubber bung (stopper) insertion. It integrates filling and stoppering in one unit under aseptic conditions, minimizing contamination risk and human intervention. It is widely used in pharmaceutical and biotech industries for injectable products like antibiotics and vaccines.

What is the typical production output of the Vial Filling and Bunging Machine?

The machine offers flexible output ranging from 30 to 250 vials per minute, depending on the model (e.g., two-head or multi-head configurations) and vial size. Two-head models are ideal for medium-scale production, while higher-capacity versions support large commercial batches. Speed can be easily adjusted using the variable AC frequency drive.

What vial sizes and fill ranges does the machine support?

It handles round glass vials with diameters of 15 mm to 70 mm and heights of 25 mm to 140 mm (typically 5 ml to 250 ml capacity). Fill volumes range from 2 ml to 250 ml for liquids and 50 mg to 10 grams for powders. It supports rubber bungs/stoppers from 13 mm to 32 mm (full or half stoppering) with quick-change parts for different formats.

What is the filling accuracy of the Vial Filling and Bunging Machine?

The machine delivers high precision with accuracy of ±0.5% to ±1% for liquids (using piston or peristaltic pumps) and ±1% to ±2% for powders (vacuum wheel system). Features like non-return valves, adjustable piston stroke, and uniform density control ensure consistent dosing across every batch.

How does the “No Vial – No Bunging” system work?

The machine uses advanced sensors for “No Vial – No Filling” and “No Vial – Machine Stop” functionality. If no vial is detected at the filling or bunging station, the machine automatically stops dosing or the entire operation to prevent product wastage, spillage, and contamination. This enhances safety and efficiency in sterile environments.

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