Vial Liquid Filling Machine

Description

Vial Liquid Filling Machine (also known as the Injection Vial Filling Machine) is a small device that is intended to fill liquid injection vials used in pharmaceuticals. It also includes a stoppering machine. The monobloc machine known as a filler is capable of doing both filling and stoppering/bunging tasks on the same platform. For GMP compliance, all continuous parts are constructed from stainless steel or FDA-approved materials. There are several filling pump alternatives that offer ±1% filling precision. Additionally, we provide a fully automated Vial Filling Sealing Labelling Line with our Vial Cap Sealing Machine and Vial Labling Machine. The output of our filler range is between 20 and 250 VPM.

The vial filling component of the machine is responsible for dispensing precise amounts of liquid product into each vial. The rubber stoppering component inserts a rubber stopper into the vial to prevent contamination or leakage, and the cap sealing component applies a closure to the vial to complete the sealing process. This type of machine is designed to perform several functions in a single operation, making it a highly efficient and effective tool for pharmaceutical manufacturing.

These machines are typically used in high-volume production settings, where accuracy, speed, and reliability are crucial for efficient production. They are also often used in cleanroom environments to ensure that products are produced in a sterile and controlled environment. Overall, vial filling, rubber stoppering, and cap sealing machines are essential tools for pharmaceutical manufacturing, enabling manufacturers to produce high-quality products with speed, efficiency, and precision.

  • Vial Feeding: Empty vials are loaded and aligned on a conveyor.

 

  • Preparation: Vials pass through washing/sterilization under laminar airflow in a Class 100 cleanroom environment.

 

  • Filling: Needles or nozzles dispense the liquid at controlled speeds; nitrogen flushing may be added to displace oxygen and extend shelf life.

 

  • Closing: Stoppers are inserted, and caps are applied, often with 100% in-process verification.

 

  • Output: Filled vials are ejected for further processing at rates from 100–600 vials per minute, depending on the model.

Working Principle of Vial Liquid Filling Machine

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Vial Liquid Filling Machine

Model

ALVF-40

ALVF-80

ALVF-120

ALVF – 250

Filling Heads

Two

Four

Eight

Twelve

Production Rate

Up to 40 Vials/Minute

Up to 80 Vials/Minute

Up to 150 Vials/Minute

Up to 250 Vials/Minute

Input Specification

    

Vial Diameter

15mm to 70mm

15mm to 70mm

15mm to 70mm

15mm to 70mm

Vial Height

25mm to 140mm

25mm to 140mm

25mm to 140mm

25mm to 140mm

  

Filling Precision

±1%

±1%

±1%

±1%

Power Required

1 H.P.

1.5 H.P.

2 H.P.

2 H.P.

Electrical Characteristics

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

Overall Dimension

2050mm (L) x 850mm (W) x 1700mm (H)

2200mm (L) x 850mm (W) x 1700mm (H)

3000mm (L) x 945mm (W) x 1700mm (H)

3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Applications of Vial Liquid Filling Machine

Benefits of Vial Liquid Filling Machine

Precision and Compliance: Ensures exact dosing (±0.05–0.5%) and sterility, reducing rejects via features like re-stoppering.

Efficiency: Boosts throughput while integrating with downstream processes like freeze-drying for extended shelf life.

Versatility: Handles various liquids (e.g., oncology drugs, vaccines) and formats in cleanrooms.

Safety: Includes safeguards like no-bottle sensors and HEPA filtration to protect operators and products.

Key Components of Vial Liquid Filling Machine

Vial liquid filling machines are modular and often integrated into complete production lines. Common components include:

 

  • Unscrambler and Conveyor: Orient and transport vials to the filling station via a belt or rotary system.

 

  • Washing and Sterilizing Stations: Clean vials internally and externally using deionized water, air drying, and depyrogenation with hot air or steam to remove endotoxins.

 

  • Filling Heads/Nozzles: Servo-controlled peristaltic, piston, or time-pressure pumps deliver precise volumes without contact to avoid contamination.

 

  • Stoppering and Capping Unit: Inserts rubber stoppers and applies aluminum seals or crimps for secure closure.

 

  • Inspection Systems: Inline sensors for weight checking, leak detection, particle inspection, and container integrity.

 

  • Control Systems: PLC-based with touchscreens for real-time monitoring, recipe storage, and integration with lyophilizers or labeling machines.

FAQ for Vial Liquid Filling Machine

The machine is available in different models:

  • ALVF-40 (2 Heads): Up to 40 vials/min
  • ALVF-80 (4 Heads): Up to 80 vials/min
  • ALVF-120 (8 Heads): Up to 150 vials/min
  • ALVF-250 (12 Heads): Up to 250 vials/min

Output depends on vial size, fill volume, and liquid viscosity. Speed is easily adjustable with a variable AC frequency drive.

The machine handles 2 ml to 250 ml fill volumes.

  • Vial Diameter: 15 mm to 70 mm
  • Vial Height: 25 mm to 140 mm

It supports quick changeover with minimal change parts for different vial formats and is compatible with various rubber stoppers (full or half stoppering).

The Vial Liquid Filling Machine offers a filling accuracy of ±1% (or better depending on liquid characteristics). It uses high-precision SS 316L syringes, piston pumps with non-return valves, and a diving nozzle system with cam-operated movement to ensure accurate, drip-free, and foam-free filling.

Key features include:

  • “No Vial – No Filling” system
  • All product contact parts in SS 316L
  • Compatibility with Class 100 laminar airflow
  • Nitrogen flushing (pre & post filling) option
  • Digital vial counter and variable speed control
  • Easy-to-clean and autoclavable parts

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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