

Vial Powder Filling and Plugging Machine is a specialized, high-precision system engineered for the aseptic filling of injectable glass vials with sterile dry powder. Also known as the Automatic Vial Powder Filling Machine or Injectable Dry Powder Filling with Rubber Stoppering Machine, it is widely trusted in pharmaceutical manufacturing for its accuracy, reliability, and strict compliance with sterile processing standards. As a leading manufacturer with extensive expertise in aseptic and sterile powder filling technology, we design these machines to deliver consistent performance, regulatory compliance, and long-term return on investment for pharmaceutical companies producing powder injectables.
Built with 316L quality stainless steel for all product-contact parts, our vial powder filling machines fully meet GMP requirements. The robust design includes conveyor belts, infeed and outfeed turntables, pre-gassing and post-gassing stations, and advanced filling mechanisms. Easy access for cleaning and maintenance is enabled through a compact control panel and high-quality synthetic rubber tubing. We offer a wide range of models — from traditional monolithic mechanical machines to cutting-edge servo-driven aseptic vial powder filling machines with centralized piston adjustment. These systems are capable of handling micro-doses of sterile powder with exceptional precision.
The Automatic High Speed Injectable Dry Powder Filling Machine features a self-picking roller-based rubber stoppering technology that operates entirely mechanically, ensuring durability for extended working hours. Powder filling is achieved through a vacuum and air pressure-based powder wheel with manual or servo-controlled fill weight adjustment. This technology guarantees accurate dosing while maintaining sterility throughout the process.
Our vial powder filling and rubber stoppering machines follow a carefully validated sequence:
Our machines stand out due to their heavy-duty construction, high-speed capability, minimal maintenance requirements, and superior filling accuracy. They are designed for high-volume production environments while maintaining the strictest sterility standards essential for injectable powders. With decades of hands-on experience in pharmaceutical equipment engineering, we provide not just machines but complete, validated solutions backed by technical expertise and dedicated support. Our vial powder filling and plugging machines help manufacturers achieve efficient, compliant, and high-quality production of sterile powder injectables. For reliable, GMP-compliant dry powder filling technology that delivers both performance and peace of mind, trust our proven aseptic filling systems.
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
A Vial Powder Filling & Plugging Machine is a compact monoblock system designed for high-speed, aseptic filling of sterile injectable powders into glass vials followed by automatic rubber stoppering (plugging). It uses a vacuum-based powder wheel system and is ideal for antibiotics and other dry powder injections in pharmaceutical manufacturing.
The machine is available in two main models:
It supports vial sizes from 5 ml to 250 ml and fill volumes from 50 mg to 10 grams per vial.
The machine offers a filling accuracy of ±2% to ±3% (depending on powder bulk density and uniformity). Accuracy is achieved through precise piston depth adjustment in the powder wheel ports and consistent vacuum + compressed air/nitrogen dosing.
The machine uses an eight-port powder wheel with vacuum suction. Sterile powder from an agitated hopper is drawn into the ports. Excess powder is removed by a doctor blade for uniform density. Compressed air (or nitrogen) then flushes the exact dose into the vial. This is followed by immediate rubber stoppering to maintain sterility.
Key anti-wastage features include:
United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba
Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Algeria | Angola | Argentina | Australia | Austria | Bahrain | Bangladesh | Belarus | Belgium | Bolivia | Botswana | Brazil | Bulgaria | Canada | Chile | China | Colombia | Costa Rica | Cuba | Czech Republic | Denmark | Dominican Republic | Ecuador | Egypt | El Salvador | Ethiopia | Finland | France | Germany | Ghana | Greece | Guatemala | Haiti | Honduras | Hong Kong | Hungary | India | Indonesia | Iran | Ireland | Israel | Italy | Ivory Coast | Japan | Jordan | Kazakhstan | Kenya | Kuwait | Lebanon | Libya | Malaysia | Mexico | Mongolia | Morocco | Mozambique | Myanmar | Netherlands | New Zealand | Nicaragua | Nigeria | Norway | Oman | Pakistan | Panama | Paraguay | Peru | Philippines | Poland | Portugal | Qatar | Romania | Russia | Saudi Arabia | Senegal | Slovakia | Singapore | South Africa | South Korea | South Sudan | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Tanzania | Thailand | Trinidad and Tobago | Tunisia | Turkey | Uganda | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Uzbekistan | Venezuela | Vietnam | Zambia | Zimbabwe
Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
©Adinath International | Theme Developed By Pharma Machinery Manufacturer I Website updated on: 21 August 2026
WhatsApp us