

The Onion Skin Ampoule Filling Machine is a specialized, high-performance equipment designed for accurate filling and reliable sealing of glass ampoules. Also known as the Onion Skin Ampoule Filler Sealer, this advanced system plays a critical role in maintaining product sterility and quality across multiple industries. As a trusted manufacturer with extensive experience in pharmaceutical packaging machinery, we understand the stringent requirements of modern production environments. Our Ampoule Filling and Sealing Machines are widely used in the pharmaceutical, biotech, cosmetic, veterinary, and chemical sectors. They are ideal for handling injectable liquids, vaccines, diagnostic solutions, essential oils, and sensitive chemical formulations that require complete protection from contamination.
The Onion Skin Ampoule Filling and Sealing Machine is a state-of-the-art solution engineered for precision filling and sealing of glass ampoules. Leveraging the advanced slant motion principle, this high-speed ampoule filling machine efficiently accommodates a wide range of ampoule neck dimensions, thicknesses, and ovality variations. It supports ampoules with diameters of 6 to 15 mm and lengths of 55 to 150 mm, making it highly versatile for standard ampoules as well as biological indicators. As a trusted manufacturer with years of expertise in pharmaceutical machinery, we understand the critical importance of maintaining sterility throughout the production process. That’s why our Onion Skin Ampoule Filler Sealer Machine operates with minimal human contact, significantly reducing the risk of contamination during filling and sealing. This design aligns with stringent cGMP and international regulatory standards, ensuring product safety for sensitive injectable formulations.
The sterilized ampoule tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers ampoules, one by one on moving eccentric ampoule rack in single/double/four/six/eight. During the movement of ampoule machine perform below mentioned operations:
At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. Ampoules now can be collected for further inspection and/or sticker labeling operations.
Model | OFS-1 | OFS-2 | OFS-4 | OFS-8 |
| Filling Heads | Single | Two | Four | Eight |
Ampoule Size Range | 1ml to 30ml | 1ml to 30ml | 1ml to 10ml | 1ml to 20ml |
| Filling Speed | Up to 25 ampoules per minute | Up to 50 ampoules per minute | Up to 100 ampoules per minute | Up to 200 ampoules per minute |
Power Requirement | 0.5 H.P. | 1.0 H.P. | 1.0 H.P. | 2.0 H.P. |
| Machine Dimensions | 915mm (L) x 610mm (W) x 965mm (H) approx. | 915mm (L) x 760mm (W) x 965mm (H) approx. | 1200mm (L) x 1070mm (W) x 965mm (H) approx. | 2200mm (L) x 1400mm (W) x 1100mm (H) approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
The Onion Skin Ampoule Filling Machine (Models OFS-1, OFS-2, OFS-4 & OFS-8) is a fully automatic, compact monoblock cGMP-compliant machine specially designed for filling and hermetically sealing thin-walled onion skin ampoules (also known as crushable glass tubes or biological indicator tubes). It uses volumetric piston pumps for precise filling and LPG + Oxygen flame sealing. The slant travelling mechanism with gentle ampoule neck centering handles variations in glass thickness (0.3–0.8 mm), neck dimensions, and ovality without breakage. It is ideal for packaging agro-insecticides, veterinary products, cosmetics, chemicals, diagnostic reagents, and biological indicators.
Production capacity varies by model:
This gives a maximum output of up to 12,000 ampoules per hour. Speed is adjustable via variable frequency drive, and actual output depends on ampoule size, fill volume, and product viscosity. It is suitable for both medium and high-volume production of thin onion skin tubes.
The machine is engineered for small, thin onion skin ampoules with diameter 6–15 mm and length 55–150 mm (minimum 7 mm diameter × 55 mm height). It supports:
It delivers ±1% filling accuracy and easily accommodates variations in glass thickness and ovality thanks to the specialized slant travel design and neck centering system.
Yes. It features pre-, during, and post-nitrogen flushing with ampoule neck centering to remove oxygen, prevent oxidation, and maintain product stability and sterility. Additional features include a “No Ampoule – No Filling” system to eliminate wastage, a pre-heating station, and precise flame sealing. All product contact parts are made of SS 316L, and the machine is fully cGMP compliant, making it suitable for sensitive liquids, biological indicators, and contamination-free processing in cleanroom environments.
Key features include:
Benefits: Gentle handling to prevent breakage of delicate thin glass, high-speed production, excellent dosing precision, superior sterility assurance, reduced product wastage, hermetic sealing for longer shelf life, and minimal human intervention. Optional PLC/HMI, servo filling, peristaltic pumps, and laminar airflow are also available.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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