Onion Skin Ampoule Filling Machine

Description

The Onion Skin Ampoule Filling Machine is a specialized, high-performance equipment designed for accurate filling and reliable sealing of glass ampoules. Also known as the Onion Skin Ampoule Filler Sealer, this advanced system plays a critical role in maintaining product sterility and quality across multiple industries. As a trusted manufacturer with extensive experience in pharmaceutical packaging machinery, we understand the stringent requirements of modern production environments. Our Ampoule Filling and Sealing Machines are widely used in the pharmaceutical, biotech, cosmetic, veterinary, and chemical sectors. They are ideal for handling injectable liquids, vaccines, diagnostic solutions, essential oils, and sensitive chemical formulations that require complete protection from contamination.

The Onion Skin Ampoule Filling and Sealing Machine is a state-of-the-art solution engineered for precision filling and sealing of glass ampoules. Leveraging the advanced slant motion principle, this high-speed ampoule filling machine efficiently accommodates a wide range of ampoule neck dimensions, thicknesses, and ovality variations. It supports ampoules with diameters of 6 to 15 mm and lengths of 55 to 150 mm, making it highly versatile for standard ampoules as well as biological indicators. As a trusted manufacturer with years of expertise in pharmaceutical machinery, we understand the critical importance of maintaining sterility throughout the production process. That’s why our Onion Skin Ampoule Filler Sealer Machine operates with minimal human contact, significantly reducing the risk of contamination during filling and sealing. This design aligns with stringent cGMP and international regulatory standards, ensuring product safety for sensitive injectable formulations.

Working Principle of Onion Skin Ampoule Filling Machine

The sterilized ampoule tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers ampoules, one by one on moving eccentric ampoule rack in single/double/four/six/eight. During the movement of ampoule machine perform below mentioned operations:

 

  • Pre-gassing with Nitrogen

 

  • Filling the product

 

  • Post Gassing with Nitrogen

 

  • Pre-heating with LPG & Oxygen combination

 

  • Sealing with LPG & Oxygen combination

 

At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. Ampoules now can be collected for further inspection and/or sticker labeling operations.

Technical Specification of Onion Skin Ampoule Filling Machine

Model

OFS-1OFS-2OFS-4OFS-8
Filling HeadsSingle​TwoFour​

Eight​

Ampoule Size Range

1ml to 30ml1ml to 30ml​1ml to 10ml​1ml to 20ml​
Filling SpeedUp to 25 ampoules per minuteUp to 50 ampoules per minute​Up to 100 ampoules per minute

Up to 200 ampoules per minute​

Power Requirement

0.5 H.P.​1.0 H.P.​1.0 H.P.​2.0 H.P.​
Machine Dimensions915mm (L) x 610mm (W) x 965mm (H)​ approx.915mm (L) x 760mm (W) x 965mm (H)​ approx.1200mm (L) x 1070mm (W) x 965mm (H)​ approx.

2200mm (L) x 1400mm (W) x 1100mm (H)​ approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Onion Skin Ampoule Filling Machine

High Precision: Ensures accurate dosing (±1% or better) for small volumes.

Sterility: Sealed environment and gas flushing prevent contamination.

Versatility: Handles a wide range of ampoule sizes and liquid viscosities (free-flowing to heavy oils).

Efficiency: High output and tool-less changeover reduce downtime.

Reliability: Robust stainless steel construction ensures durability and low maintenance.

Key Features of Onion Skin Ampoule Filling Machine

  • Design and Construction:
    • Material: Built with high-quality stainless steel, with contact parts made of AISI SS 316L and non-contact parts of AISI SS 304, ensuring compliance with cGMP (Current Good Manufacturing Practices) and FDA standards for sterile and hygienic operations.
    • Frame: Stainless steel square pipe frame with a matt finish, designed for durability and ease of cleaning. A large opening at the bottom facilitates maintenance.
    • Compact Design: Monobloc design integrates filling and sealing operations on a single platform, reducing contamination risks and ensuring cleanroom compatibility.

 

  • Filling and Sealing Mechanism:
    • Filling Principle: Operates on volumetric piston pumps or peristaltic pumps for high precision (up to ±1% accuracy), capable of filling volumes from 0.2ml to 25ml in a single dose.
    • Sealing Process: Uses oxyhydrogen flame (generated from water electrolysis) or traditional oxygen and LPG (propane) for sealing, with specially designed burners suited for thin glass (0.3mm to 0.8mm). The oxyhydrogen flame reaches temperatures up to 2800°C for fast, high-quality sealing.
    • Pre-Warming Station: Includes a pre-warming unit to heat ampoules before sealing, ensuring a secure and uniform seal.
    • Gas Flushing: Offers nitrogen or argon flushing before and after filling to protect sensitive products from oxidation or contamination.

 

  • Ampoule Handling:
    • Size Compatibility: Handles ampoules with a minimum diameter of 6mm to 7mm and a minimum height of 55mm, with no upper limit for diameter or height (customizable). Suitable for 1ml to 30ml ampoules with minimal changeover parts.
    • Slant Travel Principle: Ampoules travel at an angle during filling and sealing to accommodate variations in neck dimensions, thickness, and ovality, ensuring consistent performance.
    • Neck Centering: Precise centering of ampoule necks during pre-heating, post-heating, gas flushing, and filling operations to ensure accuracy and avoid breakage.
    • Rotation: Ampoules are rotated during pre-warming and sealing to achieve uniform heating and sealing.

 

  • Operation Process:
    • Infeed and Loading: Sterilized ampoules are loaded into a slant hopper, then fed one by one via a synchronized star wheel onto an eccentric moving rack in single, double, four, six, or eight units per stroke, depending on the machine model.
    • Sequential Operations:
      • Pre-Gassing: Nitrogen or argon is flushed to purge air from the ampoule.
      • Filling: Liquid is dispensed with high precision using piston or peristaltic pumps.
      • Post-Gassing: Additional gas flushing to protect the filled product.
      • Pre-Heating: Low-pressure flame warms the ampoule neck for sealing.
      • Sealing: High-temperature flame seals the ampoule, with specially designed rollers rotating the ampoule for a uniform seal.
    • Collection: Filled and sealed ampoules are automatically discharged onto a collection tray (often with a “dead tray” for upright placement) without human contact, minimizing contamination.

 

  • Production Capacity:
    • Output ranges from 10 to 250 ampoules per minute, depending on the model (single-head, double-head, four-head, six-head, or eight-head). For example:
      • Single-head: ~25–50 ampoules/min (lab-scale).
      • Four-head: ~100–150 ampoules/min (medium-scale).
      • Eight-head: Up to 300 ampoules/min (high-speed production).
    • Specific case: The FPS1-OS-SS model fills 6.7mm x 60mm onion skin tubes with 0.1ml to 0.4ml at 45–50 ampoules/min with ±0.5% accuracy.

 

  • Additional Features:
    • Tool-Less Changeover: Minimal parts needed for switching between ampoule sizes (1ml to 20ml), enhancing productivity.
    • Safety and Maintenance: Pendant-type electrical control panel for ease of operation and safety. Large bottom opening for easy cleaning and maintenance.
    • Customization: Available in standard and custom models to meet specific industry requirements, including biological indicator tubes.
    • Certifications: CE-certified and compliant with cGMP and FDA standards for aseptic manufacturing.
    • Eco-Friendly Option: Some models use oxyhydrogen gas generators (HHO technology) instead of traditional gas cylinders, reducing explosion risks and operational costs.

FAQ for Onion Skin Ampoule Filling Machine

Production capacity varies by model:

  • OFS-1 (Single Head): Up to 25 ampoules per minute
  • OFS-2 (Double Head): Up to 50 ampoules per minute
  • OFS-4 (Four Head): Up to 100 ampoules per minute
  • OFS-8 (Eight Head): Up to 200 ampoules per minute

This gives a maximum output of up to 12,000 ampoules per hour. Speed is adjustable via variable frequency drive, and actual output depends on ampoule size, fill volume, and product viscosity. It is suitable for both medium and high-volume production of thin onion skin tubes.

The machine is engineered for small, thin onion skin ampoules with diameter 6–15 mm and length 55–150 mm (minimum 7 mm diameter × 55 mm height). It supports:

  • 1 ml to 30 ml ampoules (model dependent: 1 ml to 30 ml on single/double head, up to 20 ml on higher heads)
  • Fill volumes from 0.5 ml to 25 ml in a single dose

It delivers ±1% filling accuracy and easily accommodates variations in glass thickness and ovality thanks to the specialized slant travel design and neck centering system.

Yes. It features pre-, during, and post-nitrogen flushing with ampoule neck centering to remove oxygen, prevent oxidation, and maintain product stability and sterility. Additional features include a “No Ampoule – No Filling” system to eliminate wastage, a pre-heating station, and precise flame sealing. All product contact parts are made of SS 316L, and the machine is fully cGMP compliant, making it suitable for sensitive liquids, biological indicators, and contamination-free processing in cleanroom environments.

Key features include:

  • Specialized slant travelling mechanism designed for thin & crushable onion skin ampoules
  • Volumetric piston pump filling with ±1% accuracy
  • Multi-stage nitrogen flushing (pre, during & post) with neck centering
  • Pre-heating station and accurate LPG + Oxygen flame sealing with flow meters
  • “No Ampoule – No Filling” system and dead tray for rejected ampoules
  • SS 316L contact parts and compact cGMP-compliant design
  • Minimum changeover time, easy cleaning, and low maintenance

Benefits: Gentle handling to prevent breakage of delicate thin glass, high-speed production, excellent dosing precision, superior sterility assurance, reduced product wastage, hermetic sealing for longer shelf life, and minimal human intervention. Optional PLC/HMI, servo filling, peristaltic pumps, and laminar airflow are also available.

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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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