Single Stroke Ampoule Filling Machine

Q: How does the Single Stroke Ampoule Filling Machine work?

The machine works on the slant movement principle . Pre-sterilized ampoules are loaded into the hopper and transferred one by one via a rectangular feeding system. In each stroke, the ampoule goes through synchronized stations: Pre-gassing (nitrogen flushing) with neck centering Precise volumetric filling Post-gassing (optional nitrogen flushing) Pre-heating and flame sealing using LPG & Oxygen burners while the ampoule rotates for a uniform hermetic seal Filled and sealed ampoules are automatically collected in an SS tray without human contact. It includes a “No Ampoule – No Fill” system to avoid wastage.

Description

The Single Stroke Ampoule Filling Machine is an advanced pharmaceutical processing solution engineered for the accurate filling and sealing of sterile liquid formulations in glass ampoules. Designed to handle a wide range of liquid viscosities—from free-flowing solutions to highly viscous oils—this machine is widely used across the pharmaceutical, biotechnology, chemical, cosmetic, and research industries. Its reliable performance, precision engineering, and compliance with pharmaceutical manufacturing standards make it an ideal choice for laboratories, pilot plants, and commercial production facilities. Built using high-grade stainless steel construction, the machine ensures exceptional durability, corrosion resistance, and easy maintenance. The robust SS square pipe frame is fully enclosed with a premium matte-finished stainless steel body, offering excellent hygiene and easy cleaning. A large bottom-side opening allows convenient access for thorough washing and maintenance, supporting GMP-compliant manufacturing environments.

The working principle of the Glass Ampoule Filling and Sealing Machine is based on the slant movement of ampoules during filling and sealing. This unique design compensates for variations in ampoule neck dimensions, glass thickness, and manufacturing tolerances, ensuring consistent filling accuracy and reliable sealing quality. Whether processing standard pharmaceutical ampoules, glass tubes, onion skin tubes, vials, or similar containers, the machine delivers dependable performance with minimal product loss. This fully automatic Ampoule Filling and Sealing Machine integrates multiple operations into a single compact system. It performs automatic ampoule feeding, synchronized transfer, pre- and post-nitrogen purging, precise liquid filling, flame heating, and hermetic sealing without manual intervention. The integrated “No Ampoule, No Filling” mechanism eliminates product wastage by ensuring filling only occurs when an ampoule is correctly positioned. This intelligent feature is especially valuable when handling expensive injectable formulations, vaccines, biologics, and specialty pharmaceutical products.

The filling system supports ampoule capacities ranging from 1 ml to 25 ml, with a single-dose filling accuracy suitable for volumes between 0.5 ml and 25 ml. Depending on the ampoule size and product characteristics, the machine delivers an efficient production output of approximately 10 to 25 ampoules per minute, making it suitable for research batches, pilot production, and small-to-medium manufacturing requirements. One of the standout features of this Automatic Ampoule Filling Machine is its innovative rectangular feeding mechanism, which replaces conventional ampoule feeding systems. This advanced design significantly improves ampoule stability throughout the production process, reducing the risk of breakage while maintaining smooth and continuous operation. Combined with precise synchronization of filling and sealing stations, the machine consistently delivers high-quality, contamination-free finished products. Manufactured using precision engineering and stringent quality control standards, our Single Stroke Ampoule Filling Machine provides pharmaceutical manufacturers with reliable performance, repeatable filling accuracy, and long-term operational efficiency. Its user-friendly operation, low maintenance requirements, and dependable sealing technology make it a trusted solution for sterile injectable production. Whether you are developing new pharmaceutical formulations in an R&D laboratory or producing commercial batches, this machine offers the precision, safety, and reliability required to meet modern pharmaceutical manufacturing demands.

Loading: Empty, pre-sterilized syringes or ampoules are loaded into a hopper or conveyor.

Filling: A precise volume of liquid is dispensed via a pump or piston system, often with nitrogen flushing to maintain sterility.

Sealing: Syringes are stoppered, or ampoules are sealed using gas flames or vacuum systems, with pre-warming to ensure quality seals.

Inspection: Automated checks for fill accuracy, particle presence, and container integrity.

Ejection: Filled and sealed containers are collected in trays for further processing or packaging.

For further details or purchasing options, you can explore manufacturers like Adinath International.

Salient Features of Single Stroke Ampoule Filling Machine

Compact cGMP model.
Production output up to 1800 ampoules/hour.
Equipped with pre-warming station for perfect sealing operations.
“No Ampoule – No Filling” system.
Flow Meters for regulating flames easily.
Full accessibility allows easy maintenance.

All contact parts made from high quality Stainless Steel 316 & other Non-contact parts made from Stainless Steel 304.
Ampoule neck centering during gas flushing and filling operations.
Suitable to fill 1ml to 20ml ampoule size and minimum change over parts from one size to another.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Single Stroke Ampoule Filling Machine

Empty washed & sterilized ampoules fed into in-feed hopper from the left hand side of the machine to receiving rack. The moving rack which moves horizontally collect one ampoule from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position through pre-gassing. Pre-gassing, Filling, Post Gassing, Pre-heating & sealing stations completes filling & sealing operations. Filled & sealed ampoules are collected automatically in SS tray in upright position without hand touch.

The machine performs the following operations:

Ampoule feeding by in-feed hopper, cassettes and ampoule transfer into transport rack.

One ampoule advanced per machine stroke.

Centering of ampoules necks during pre-heating, post heating, gas flushing and liquid filling.

Rotation of ampoules neck in the pre- heating and heating station.

Elimination of burdened-off ampoule tips by clippers and ejection into a separate container.

Technical Specification of Single Stroke Ampoule Filling Machine

Model	AFS-30
Production Output	Up to 25 ampules/minute
Ampoule Size	1ml to 30ml
Filling Accuracy	± 1%
Require Gas for Sealing	LPG & Oxygen (O₂)
Nitrogen Flushing	Pre & Post Nitrogen Flushing Available
Power Specification	0.5 H. P.
Electrical Characteristics	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non Contact Parts	Made from Stainless Steel 304
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.
Net Weight	150 Kgs. approx.
Gross Weight	225 Kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Single Stroke Ampoule Filling Machine

Compact and cost-effective for small to medium batch production.

Minimal changeover parts for different ampoule sizes (1ml to 20ml), reducing downtime.

Easy maintenance and cleaning due to accessible design.

Ensures sterile, precise filling and sealing, maintaining product integrity.

Key Features of Single Stroke Ampoule Filling Machine

Operation: Empty, sterilized ampoules are loaded into an in-feed hopper and transferred to a transport rack via a star wheel. The machine performs sequential operations: pre-gassing (often with nitrogen), filling, post-gassing, pre-heating, and sealing. Filled and sealed ampoules are collected automatically in an upright position without manual handling.

Capacity: Suitable for filling 1ml to 25ml ampoules with a filling range of 0.5ml to 25ml in a single dose.

Material: Contact parts are typically made of high-quality Stainless Steel 316L, and non-contact parts use Stainless Steel 304, ensuring compliance with cGMP standards.

Design: Built on a stainless steel square pipe frame with a matt finish, featuring a large bottom opening for easy cleaning and maintenance. A pendant-type electrical control panel enhances operational ease and safety.

Nitrogen Flushing: Offers optional nitrogen gas flushing before, during, and after filling to prevent oxidation and ensure product stability.

Sealing: Uses oxygen and LPG (propane) for precise sealing, with rollers rotating ampoules during sealing for uniform closure. Waste glass tips are clipped and ejected into a separate container.

Applications: Widely used for filling injectable liquids, veterinary medicines, agro-insecticides, and cosmetic products.

FAQ for Single Stroke Ampoule Filling Machine

What is a Single Stroke Ampoule Filling Machine?

A Single Stroke Ampoule Filling Machine is a compact, precision equipment designed to fill and hermetically seal glass ampoules with sterile liquids such as injectables, vaccines, antibiotics, and serums. It operates on a single-stroke (one ampoule per cycle) slant-travel principle, making it ideal for small to medium batch production, R&D laboratories, and pilot-scale manufacturing. The machine performs nitrogen flushing, accurate volumetric filling, pre-heating, and flame sealing in one automated process while maintaining high sterility and cGMP compliance.

What is the production capacity and ampoule size range of the Single Stroke Ampoule Filling Machine?

The Single Stroke Ampoule Filling Machine (Model AFS-30) has an output of up to 25 ampoules per minute (approximately 1,500–1,800 ampoules per hour, depending on ampoule size). It can handle 1 ml to 30 ml glass ampoules with a filling range of 0.5 ml to 25 ml in a single dose. The machine supports open-mouth ampoules and offers quick changeover with minimum change parts for different sizes (especially 1 ml to 20 ml).

How does the Single Stroke Ampoule Filling Machine work?

The machine works on the slant movement principle. Pre-sterilized ampoules are loaded into the hopper and transferred one by one via a rectangular feeding system. In each stroke, the ampoule goes through synchronized stations:

Pre-gassing (nitrogen flushing) with neck centering
Precise volumetric filling
Post-gassing (optional nitrogen flushing)
Pre-heating and flame sealing using LPG & Oxygen burners while the ampoule rotates for a uniform hermetic seal

Filled and sealed ampoules are automatically collected in an SS tray without human contact. It includes a “No Ampoule – No Fill” system to avoid wastage.

What are the key features and benefits of the Single Stroke Ampoule Filling Machine?

Key features include:

Compact cGMP model with SS 316L contact parts and SS 304 non-contact parts
“No Ampoule – No Filling” system
Pre & post nitrogen flushing facility
Pre-warming station for perfect sealing
Flow meters for easy flame regulation
High filling accuracy of ±1% (optimizable to ±0.5%)
Low power consumption (0.5 HP) and easy maintenance

Benefits: It is highly suitable for low-to-medium volume production, reduces product wastage, ensures excellent sterility, requires minimal changeover time, and is easy to clean and operate — making it cost-effective for R&D, pilot plants, and small-scale injectable manufacturing.

Is the Single Stroke Ampoule Filling Machine compliant with regulations, and what about maintenance?

Yes, the machine is fully cGMP compliant and built with high-quality stainless steel to meet pharmaceutical standards. It requires LPG & Oxygen for sealing and can be integrated with laminar airflow for a Class 100 environment. Maintenance is straightforward due to full accessibility, minimal moving parts, and easy cleaning design. We provide detailed operation manuals, operator training, and prompt after-sales support with spare parts availability to ensure long-term reliability and minimal downtime.

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