Automatic Six Head Ampoule Filling Machine

Description

The ideal option for filling and sealing glass ampoules is an automatic Six Head Ampoule Filling Machine. Several industries have used ADINATH’s six head ampoule filling and Sealing Machine. The pharmaceutical, biotechnology, cosmetic, veterinary, and chemical industries all choose ADINATH’s ampoule filling machines. The Adinath International Automatic six-head ampoule filling and sealing machine uses the Angle Travel principle and has an enhanced filling capacity of 0.5 to 10 millilitres, making it suitable for a range of ampoule sizes from 1 to 10 millilitres with an open mouth. Depending on their sizes, the machine with six heads can boost the output to 80 to 150 ampoules per minute. This model can fill and seal up to 150 ampoules per minute, with a minimum of 80 ampoules per minute. The ampoule filler machine is designed to accommodate the vast range of ampoule neck diameters, thicknesses, and ovality of available ampoules by using the principle of slant movement of ampoules during filling and sealing. The unit is constructed on a S. S. Square pipe frame, completely covered with S. S. coverings, and has a beautiful matt surface. It also has a huge aperture on the bottom side for complete cleaning. For convenience and security, the pendant-style electrical control panel is raised from the machine.

Strong, heavy-duty stainless steel components are used in the production of our six-head filler and sealer. The creation of ampoule filling machines, which are CE certified and have DUNS numbers, began with Adinath International, a reputable producer of pharmaceutical machinery. As needed, ampoule filling and sealing machines are exported to a number of foreign locations. Over time, our research engineers continue to improve the equipment with new features. Additionally, we provide them customisation based on the needs of our clients.

Salient Features of Ampoule Filling Machine

Compact cGMP model.
Higher output up to 9000 Ampoules per hour.
Machine equipped with pre-warming station.
“No Ampoule – No Filling” system.
Flow Meters for regulating flames easily.
Full accessibility allows easy maintenance.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Ampoule neck centering during gas flushing and filling operations.
Minimum change over parts from 1ml to 10ml ampoule size.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Automatic Six Head Ampoule Filling Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect six ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Filling and Sealing Process:

- Ampoule Handling: Sterilized ampoules are loaded into a slant hopper, and a synchronized star wheel delivers them one by one (or in groups of six) to an eccentric transport rack. The rack pauses sequentially for pre-gassing, filling, post-gassing, pre-heating, and sealing operations.
- Filling Capacity: Suitable for filling 0.5ml to 10ml or 1ml to 20ml ampoules, depending on the model. Some machines support up to 30ml with minimal changeover parts.
- Filling Mechanism: Utilizes volumetric piston pumps, peristaltic pumps, or servo-driven systems for precise liquid filling. Nitrogen flushing (pre- and post-filling) is available to prevent contamination and oxidation.
- Sealing: Features pre-warming and sealing stations using combustible gases (oxygen and LPG/propane). Specially designed rollers rotate ampoules during sealing to ensure uniform, high-quality seals with a sealing efficiency of up to 99.8%. Waste tips are clipped and collected separately.

Technical Specification of Automatic Six Head Ampoule Filling Machine

Model Name	AFS-6
Production Speed	Up to 150 ampules/minute
Ampoule Sizes	1 ml to 20 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	2 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	2000mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Benefits of Automatic Six Head Ampoule Filling Machine

High Precision: Ensures accurate dosing and reliable sealing, critical for pharmaceutical safety.

Efficiency: High output and fast changeover times boost productivity.

Flexibility: Handles a wide range of ampoule sizes and liquid types with minimal adjustments.

Aseptic Processing: Nitrogen flushing and sterile design minimize contamination risks.

Durability: Stainless steel construction ensures long-term reliability and compliance with GMP standards.

Key Components of Automatic Six Head Ampoule Filling Machine

Design and Construction:
- Principle of Operation: Built on the principle of slant travel of ampoules during filling and sealing to accommodate variations in ampoule neck dimensions, thickness, and ovality. This ensures compatibility with a wide range of standard glass ampoules.
- Material: Contact parts are made of high-quality Stainless Steel 316L, compliant with cGMP standards, while non-contact parts are typically Stainless Steel 304. This ensures durability, corrosion resistance, and hygiene.
- Frame: Constructed with a sturdy stainless steel square pipe frame, fully encompassed with stainless steel coverings in a matte finish for aesthetic appeal and ease of cleaning. A large bottom opening facilitates thorough cleaning and maintenance.

Output and Efficiency:
- Production Capacity: Typically ranges from 80 to 150 ampoules per minute, with some models achieving up to 9000 ampoules per hour for large-scale production.
- Changeover Time: Minimal changeover time for different ampoule sizes (1ml to 10ml or 20ml) due to fewer changeover parts, enhancing operational efficiency.
- No Ampoule, No Fill System: Prevents wastage of costly liquids by ensuring filling only occurs when an ampoule is present.

Additional Features:
- Control System: Equipped with a pendant-type electrical control panel for safe and easy operation. Some models include PLC and HMI for automatic fill volume adjustments and real-time monitoring.
- Safety and Compliance: CE-certified and 21 CFR Part 11-compliant models are available. Features like safety valves, pressure reducers, and stainless steel hoods for fume extraction ensure operator safety and environmental protection.
- Cooling System: Efficient cooling prevents overheating, extending machine lifespan.
- Versatility: Some models support both open and closed-mouth ampoules, with options for integration with washing, sterilization, and labeling systems for a complete production line.

Applications:
- Widely used for filling sterile injectables (e.g., vaccines, drugs), agro-insecticides, veterinary medicines, and cosmetic products. Suitable for liquids, powders, or viscous substances like oils.

Maintenance and Cleaning:
- Designed for easy maintenance with full accessibility and minimal downtime. The large bottom opening and removable parts simplify cleaning, meeting stringent aseptic requirements.

Optional Features:
- Pre-warming station for perfect sealing.
- Laminar Air Flow (LAF), isolators, or RABS (Restricted Access Barrier Systems) for enhanced sterility.
- Servo-based or peristaltic pump filling for high-precision needs.
- Combination machines for processing both ampoules and vials.

FAQ for Automatic Six Head Ampoule Filling Machine

What is an Automatic Six Head Ampoule Filling Machine?

An Automatic Six Head Ampoule Filling Machine is a high-speed pharmaceutical equipment designed to fill and seal sterile liquid products (such as injectables, vaccines, or serums) into glass ampoules. It features six filling heads that work simultaneously, enabling efficient production of up to 80–150 ampoules per minute (approximately 4,800–9,000 ampoules per hour). The machine performs volumetric filling, pre- and post-nitrogen flushing, and flame sealing in a continuous automatic process while meeting cGMP standards.

What is the filling range and accuracy of the Automatic Six Head Ampoule Filling Machine?

The machine typically handles ampoules from 1 ml to 10 ml (some models support 0.5 ml to 20 ml with change parts). It uses a precise volumetric piston or servo-based filling system with an accuracy of ±1%. This ensures consistent dosing for injectable products while minimizing product wastage.

What are the key features of this machine?

Key features include:

Compact cGMP-compliant design with stainless steel 316L contact parts
Pre- and post-nitrogen purging to prevent oxidation
Automatic ampoule feeding, filling, and flame sealing using LPG + Oxygen
Touchscreen HMI for easy operation and fill volume adjustment
Minimum changeover time for different ampoule sizes
High output with low maintenance

These features make it ideal for medium to large-scale pharmaceutical production.

What types of ampoules can this machine handle?

The Automatic Six Head Ampoule Filling Machine is suitable for open-mouth ampoules (Type B & C) as well as closed-mouth ampoules (Type D) with appropriate variants. It works efficiently with standard 1–10 ml glass ampoules used in injectable formulations.

What is the power requirement and output capacity?

The machine generally requires 1–2 HP power with 230V, single phase, 50 Hz electrical supply. Its production output ranges from 80 to 150 ampoules per minute depending on ampoule size and fill volume, making it suitable for high-volume sterile filling lines while keeping energy consumption moderate.

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