Closed Ampoule Filling Machine

• Integrated Opening, Filling & Sealing on a Single Platform The machine performs ampoule opening (drawing/neck cutting), nitrogen flushing, precise liquid filling, and flame sealing in one compact monoblock unit. This reduces handling steps, minimizes contamination risk, and saves valuable floor space.

• Compact cGMP-Compliant Design Built with high-quality Stainless Steel 316L contact parts and 304 non-contact parts, ensuring full compliance with international pharmaceutical standards (cGMP, FDA, WHO).

• Extra Station for Ampoule Opening Features a dedicated opening station to handle pre-sterilized Type D closed-mouth ampoules, making it ideal for high-sterility applications where ampoules arrive sealed from the glass manufacturer.

• High Precision Volumetric Filling Uses piston pumps or servo-driven systems with filling accuracy of ±1% (or better in advanced models). Supports a wide filling range from 0.5 ml to 25 ml (or up to 30 ml) in a single dose.

• Pre & Post Nitrogen Flushing Nitrogen gas purging before, during, and after filling removes oxygen, preventing oxidation and ensuring longer product stability for sensitive injectables.

• No Ampoule – No Filling System Advanced sensor-based system that prevents filling if an ampoule is missing, reducing product wastage and spillage.

• Ampoule Neck Centering & Pre-Warming Station Ensures accurate gas flushing and filling by centering the neck. Pre-warming helps achieve perfect flame sealing, especially with thicker glass ampoules.

• High Production Output Depending on the model (single to eight heads), output ranges from 15–30 ampoules per minute (single head) up to 100–200 ampoules per minute (multi-head), delivering up to 12,000 ampoules per hour.

• Easy Changeover & Minimum Downtime Quick-change parts for different ampoule sizes (typically 1 ml to 20/30 ml) with minimum changeover time.

• Dead Tray / Collection Tray for Upright Placement Safely collects sealed ampoules in an upright position for easy transfer to inspection or labeling stations.

• User-Friendly Operation & Maintenance Touchscreen HMI/PLC control, single synchronized motor drive, full accessibility for cleaning, and flow meters for easy flame adjustment. Low maintenance and easy validation.

• Flame Sealing with LPG + Oxygen Precise sealing using combustible gases with variable flame control for strong, hermetic seals.

These features make the Closed Ampoule Filling Machine highly suitable for sterile injectable products like vaccines, antibiotics, biologics, and oxygen-sensitive formulations where maximum sterility and product integrity are critical.