Two Head Ampoule Filling & Sealing Machine

The Two Head Ampoule Filling and Sealing Machine offers an output of up to 50 ampoules per minute (approximately 3,000 ampoules per hour). It can handle 1 ml to 30 ml glass ampoules with a filling range of 0.5 ml to 25 ml in a single dose. Minimum changeover parts are required for sizes from 1 ml to 10 ml, allowing quick format changes with excellent flexibility for different batch sizes.

The machine works on the slant (angle travel) movement principle. Pre-sterilized ampoules are fed from the hopper into a moving rack in groups of two. They then pass through synchronized stations:

• Pre-gassing with nitrogen flushing and neck centering
• Precise volumetric filling using two heads (with diving nozzles for foam-free filling)
• Post-gassing with nitrogen (before, during, or after filling)
• Pre-warming and two-stage flame sealing using LPG + Oxygen while ampoules rotate for a uniform hermetic seal

Filled and sealed ampoules are collected upright in a dead tray. It includes a “No Ampoule – No Filling” system and automatic sensors to prevent wastage and ensure accuracy.

Key features include:

• Two filling heads for higher output in a compact footprint
• “No Ampoule – No Filling” system with neck centering
• Pre & post nitrogen flushing facility (before, during, and after filling)
• Pre-warming station and flow meters for easy flame regulation
• High filling accuracy of ±1% (optimizable to ±0.5%)
• Contact parts in SS 316L and non-contact parts in SS 304
• Compact cGMP model with full accessibility and easy cleaning
• Low power consumption (0.5 HP) and minimum changeover time

Benefits: It provides a perfect balance between speed and space, reduces product wastage, ensures superior sterility, requires minimal labor and maintenance, and is highly suitable for medium-batch injectable manufacturing.

The machine requires LPG & Oxygen for sealing and supports nitrogen gas flushing. Power load is 0.5 H.P. (230 Volts, Single Phase, 50 Hz – customizable). It is fully cGMP and CE compliant, with easy-to-clean design and low maintenance. It can be integrated with laminar airflow for sterile (Class 100) operation. We provide detailed operation manuals, operator training, and reliable after-sales support with spare parts availability to ensure minimal downtime and long-term performance.