In the highly regulated pharmaceutical manufacturing industry, the Aseptic Powder Filling Machine — also widely known as a sterile powder filling machine or injectable powder filler — stands as a critical piece of equipment for producing high-quality powder injections. Designed as a fully compliant cGMP (current Good Manufacturing Practice) system, this advanced monobloc machine efficiently handles both powder filling and stoppering (bunging) operations on a single platform, minimizing contamination risks and maximizing operational efficiency.
Aseptic powder filling demands uncompromising precision, sterility, and repeatability. Our sterile powder filling machines are engineered to meet these stringent requirements. All product-contact parts are constructed from high-grade stainless steel 316L or other FDA-approved materials, ensuring full cGMP compliance and easy validation. This robust construction delivers superior cleanability, corrosion resistance, and long-term reliability in sterile manufacturing environments. The machine utilizes a sophisticated mechanical drive system combined with a self-picking roller-based rubber stoppering mechanism. Powder is accurately dosed through a specially designed powder wheel that operates on a combination of vacuum and air pressure. This innovative technology allows operators to make precise, consistent fill-weight adjustments manually, reducing powder waste significantly while maintaining excellent dose accuracy. Capable of filling up to 120 round glass vials per minute, this high-speed aseptic powder filler supports demanding production schedules without compromising quality.
Aseptic powder filling presents numerous technical hurdles, including accurate weighing, particle size control, electrostatic management, bulk powder handling, effective sealing, and stringent cleanability standards. With decades of hands-on industry experience, our technical team has mastered these challenges. We combine deep domain expertise with state-of-the-art engineering to deliver solutions that not only meet but exceed client expectations. Beyond our standard range of aseptic powder filling machines, we specialize in customized design and manufacturing. Whether your process requires unique vial sizes, specialized powder characteristics, enhanced containment, or integration with isolator technology, our engineers work closely with you to develop tailored systems. From initial consultation through installation and validation support, we provide end-to-end partnership grounded in proven pharmaceutical manufacturing knowledge.
Investing in a high-performance injectable powder filling machine translates to higher throughput, reduced product waste, consistent fill weights, and enhanced sterility assurance. Manufacturers benefit from improved yield, lower operational costs, and greater confidence during audits. Our machines are trusted by leading pharmaceutical companies worldwide for their reliability, precision, and compliance focus. At our company, we prioritize EEAT — Experience, Expertise, Authoritativeness, and Trustworthiness. Our team consists of seasoned pharmaceutical equipment specialists who understand the nuances of sterile processing. Every machine undergoes rigorous testing and quality checks before delivery, backed by comprehensive documentation and after-sales support. Ready to optimize your powder filling process? Explore our range of aseptic powder filling machines and discover how our sterile powder filling solutions can elevate your production standards while ensuring full regulatory compliance.
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.
The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
Sterile powder from the hopper is drawn into the powder wheel ports using vacuum. Excess powder is removed by a doctor blade. As the wheel indexes, low-pressure compressed air (or nitrogen) flushes the precise dose into the vial. Filled vials then move to the built-in stoppering station where sterilized rubber stoppers are automatically placed and pressed. The process maintains aseptic conditions throughout.
The machine is available in single and double head models:
It handles vial sizes from 5 ml to 250 ml and fill volumes from 50 mg to 10 grams per dose.
It offers superior sterility assurance, high filling accuracy, minimal powder wastage, and easy cleaning (removable contact parts for autoclaving). The machine reduces contamination risk, supports high-speed aseptic production, and complies with stringent regulatory standards (FDA, WHO-GMP), making it ideal for injectable powder manufacturing.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Adinath International manufactures high-precision pharmaceutical packaging machinery and production plants, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.
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