

Dry Syrup Powder Filling Machine is specialized pharmaceutical packaging equipment designed to accurately fill dry powder formulations into bottles for reconstitutable oral suspensions. These machines are widely used for packaging antibiotic dry syrups, pediatric medicines, and other moisture-sensitive powders that remain stable in dry form until water is added by the end user. The Dry Syrup Powder Filling Machine ensures precise dosing, hygienic operation, and high production efficiency while meeting strict regulatory standards.
Most modern Dry Syrup Powder Filling Machines operate using either servo-driven auger technology or a vacuum-pressure rotary system. In auger-based models, a precision screw meters the powder into bottles with high repeatability. In vacuum-pressure systems, a rotating powder wheel draws exact volumes of powder via vacuum and discharges them cleanly into bottles using sterilized air or nitrogen. Many machines feature rotary funnel systems with vibratory assistance to handle both free-flowing and semi-free-flowing powders smoothly. Bottles (glass, PET, HDPE, or PP) are automatically fed, filled, and often capped on the same monoblock platform.
Typical performance specifications include filling ranges from 5 g to 100 g or more per dose, accuracy of ±1% to ±3% (depending on powder characteristics and controlled humidity, ideally below 28–30% RH), and production speeds of 60–120 bottles per minute, with higher-output models available. Contact parts are manufactured from SS 316L stainless steel for easy cleaning and sterilization, while the frame is usually SS 304. Advanced models include “No Bottle – No Fill” interlocks, dust extraction systems, HMI touchscreens with recipe management, and optional online checkweighing.
Experience from pharmaceutical and nutraceutical production lines shows that Dry Syrup Powder Filling Machines deliver consistent fill weights, minimal powder wastage, and reliable performance across varying bottle sizes and powder types. Operators benefit from quick changeovers, reduced manual handling, and clean bottle necks that improve final product appearance and reduce cleaning requirements.
Expertise is reflected in the machine’s design. Careful control of bulk density, gentle powder handling, and humidity management protect the formulation’s integrity. Features such as agitators in the hopper, precise dosing mechanisms, and dust containment systems demonstrate deep understanding of powder flow behavior and the specific challenges of dry syrup packaging.
Authoritativeness comes from widespread use in regulated facilities. These machines are built to cGMP standards and support compliance with FDA, WHO-GMP, and other international guidelines. Established manufacturers provide validated performance data, documentation, and qualification support (IQ/OQ/PQ), making the equipment a trusted choice for both large-scale producers and contract manufacturers. Trustworthiness is built through design elements that prioritize product quality and safety. Accurate dosing ensures patients receive the correct amount of medication after reconstitution. Hygienic construction, contamination-control features, and safety interlocks help maintain product purity and support successful regulatory audits.
In summary, the Dry Syrup Powder Filling Machine offers pharmaceutical manufacturers a reliable, efficient, and cost-effective solution for packaging reconstitutable dry syrup powders. By combining precise filling technology, robust aseptic design, and high-speed performance, it plays a vital role in producing stable, high-quality oral suspensions that meet both patient needs and regulatory expectations.
Sterilized dry bottles enter the system via the in-feed turntable. Guides direct them onto a flat conveyor belt at the required feeding speed. A filling head is mounted on the machine’s top plate in line with the conveyor. When a bottle reaches the mechanical holder at the filling station, a bottle sensor detects it and activates a magnetic clutch on the auger shaft. The auger then rotates for a pre-set time, dispensing the exact quantity of powder into the bottle. Filled bottles are conveyed upward on a stainless-steel belt to the sealing station.
Models | AI-DPM 12 | AI-DPM 16 |
Production Output | Up to 80 bottles/minute | Up to 120 bottles/minute |
Bottle Diameter | Up to 85mm | Up to 85mm |
Bottle Height | Up to 200mm | Up to 200mm |
Fill Volume | 5gms. To 70gms. in Single Dose with the help of change parts for different fill volume | 5gms. To 70gms. in Single Dose with the help of change parts for different fill volume |
Fill Accuracy | ± 2% Depending upon the Powder, under the controlled level of Humidity | ± 2% Depending upon the Powder, under the controlled level of Humidity |
Humidity | Below 28% Rh required on machine to be arrange by customer | Below 28% Rh required on machine to be arrange by customer |
Power | 2.0 H.P. For Machine and 3.0 H.P. For Vacuum Pump | 2.5 H.P. For Machine and 3.0 H.P. For Vacuum Pump |
Overall Dimension | 1700 mm (L) x 1000 mm (W) x 1800 mm approx. | 2000 mm (L) x 1200 mm (W) x 1800 mm approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
Purpose: Precisely dispenses dry powders into bottles intended for oral suspensions.
Types:
Filling Range: 5–200 grams per bottle (adjustable).
Accuracy: ±2% variation, influenced by powder characteristics and humidity levels.
Output: High-speed models achieve up to 120–150 bottles per minute.
Materials: Product-contact parts fabricated from stainless steel (SS 316) to ensure hygiene and full GMP compliance.
Controls: PLC with touch-screen interface for precise volume and speed adjustments.
Safety Features: Includes no-bottle-no-fill sensors, low-pressure automatic stops, and dust-free designs equipped with neck holders.
A Dry Syrup Powder Filling Machine is specialized pharmaceutical equipment designed to accurately fill dry powder formulations (such as antibiotic dry syrups and pediatric medicines) into bottles for reconstitutable oral suspensions. It ensures precise dosing, hygienic operation, and high production efficiency while complying with cGMP standards.
Sterilized bottles are fed via an infeed turntable and conveyor. Sensors detect each bottle and activate the filling system (auger or vacuum-pressure rotary mechanism). Powder is precisely metered from the hopper and dispensed into the bottle. A vibratory funnel assists with semi-free-flowing powders. Filled bottles then move to the capping/sealing station and exit via the outfeed system.
The machine is available in models such as AI-DPM 12 (up to 80 bottles per minute) and AI-DPM 16 (up to 120 bottles per minute). Higher-output configurations can reach 120–150 bottles per minute depending on fill volume, powder characteristics, and bottle size.
It typically fills 5 g to 70 g per bottle in a single dose (adjustable with change parts; some models support up to 200 g). Filling accuracy is ±2%, depending on the powder type and when operated under controlled humidity below 28% RH.
The machine handles free-flowing and non-free-flowing (or semi-free-flowing) dry powders commonly used in oral suspensions. It accommodates glass, PET, HDPE, or PP bottles up to 85 mm in diameter and 200 mm in height, with quick changeovers for different sizes.
All product-contact parts are made of SS 316/316L stainless steel for hygiene and easy sterilization. The machine frame is constructed from SS 304. It is fully designed to cGMP standards and supports compliance with FDA, WHO-GMP, and other international regulatory guidelines.
Key safety features include “No Bottle – No Fill” interlocks, automatic stop on low air pressure or low vacuum, dust-free designs with neck holders to prevent spillage, toughened glass safety enclosure, and automatic machine start/stop when bottles are absent on the infeed conveyor.
Yes. It features tool-less adjustments for doctor and wiper blades, easy-removal contact parts, and change parts for different fill volumes and bottle sizes. This enables quick changeovers while maintaining high accuracy across various powders and containers.
Dry syrup powders are moisture-sensitive. The machine requires controlled humidity below 28–30% RH (to be arranged by the customer) to maintain consistent bulk density, ensure ±2% filling accuracy, and prevent powder bridging or degradation.
All product-contact parts are designed for easy removal, allowing thorough cleaning, autoclaving, or sterilization. The stainless-steel construction and accessible design minimize downtime. Regular lubrication of moving parts and adherence to the manufacturer’s maintenance schedule further ensure long-term reliability.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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