In the pharmaceutical sector, Powder Filling Machine for Glass Vials Bottles are primarily used for packing and stoppering sterile powder injections of control vials. In pharmaceutical plants with high production volumes, it is frequently used to package sterile powder injections of antibiotics. A precision-engineered solution for quick, precise, and hygienic powder packaging is the Adinath International Powder Filling Machine for Glass Vials Bottles. This machine guarantees consistent filling performance for sectors that demand high standards of efficiency and cleanliness since it is built with robust stainless steel components and sophisticated automation.
With a maximum speed of 120 vials per minute, the automatic vial powder filling machine is appropriate for round glass vials. According to cGMP standards, the machine is constructed with a stainless-steel finish, including the machine frame structure. For more efficient operation, the machine has built-in Turn Tables at the In-feed and Out-feed with separate motors to match the speed of entering and outgoing vials. Every component that comes into contact with powders is composed of Ss316 materials. The machine has a single head, single track, eight-port powder wheel that fills glass vials with powder using vacuum and air systems. It also has an online vibrator-style rubber stoppering system that inserts stoppers continuously at the machine’s synchronised pace. To meet the unique needs of each customer, machines are also available in a variety of variations, such as Single Track Double Powder Wheel, Double Track Double Powder Wheel, Single Track Single Powder Wheel, and Double Track Single Powder Wheel System.
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
The machine uses a vacuum-based powder wheel system (typically with an eight-port wheel). Sterile powder from an agitated hopper is drawn into the ports by vacuum according to the piston depth. Excess powder is removed by a doctor blade for uniform density. Compressed air (or nitrogen) then flushes the precise dose into the vial. Filled vials move to the built-in vibrator-type rubber stoppering station, where stoppers are pressed in place. A “No Vial, No Filling” system prevents wastage.
The machine handles round glass vials from 5 ml to 250 ml. The fill volume ranges from 50 mg to 10 grams per vial (depending on the model and powder density). It supports single or multiple dosing and is suitable for both single-track (up to 100 vials/min) and double-track (up to 200 vials/min) configurations. Change parts are available for different vial and dose ranges.
Filling accuracy is typically ±2% (or better with servo-controlled options), depending on the powder’s uniform bulk density.
Yes. It is a cGMP-compliant model designed for aseptic processing of sterile powders. All powder-contact parts are made of SS316/SS316L (FDA-approved materials) and are easily removable for autoclaving/sterilization. It features a built-in rubber stoppering unit, safety systems, and optional inbuilt Class 100 laminar airflow, making it ideal for antibiotics and other injectable powders in controlled sterile areas.
Important features include the “No Vial, No Filling” system, which prevents filling when no vial is present, a safety clutch to avoid vial breakage, individual drives for filling and stoppering, variable AC frequency drive for speed control, and overload protection. Agitators in the hopper maintain consistent powder flow and uniform density. All contact parts are designed for easy cleaning and sterilization.
Yes, the machine is highly customizable. Options include servo motors, in-process weight checking with automatic rejection, multiple dosing systems, split-filling for different powders, inbuilt laminar airflow, and different powder wheel configurations (single/double track, single/double powder wheel). It can be integrated into a complete vial washing–sterilizing–filling–capping line. We also provide IQ/OQ documentation and change parts for various vial sizes and doses.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.
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