Vial Filler and Capper

Description

Pharmaceutical glass vials are filled, stoppered, and cap sealed by  vial filler and capper. The machine features a specially developed SS 316L filling pump for accurate filling. The vial filler and sealer machine consists of a turntable, a stainless steel slat conveyor belt, and unique eccentric pre-, filling, and post-gassing. Non-toxic synthetic rubber tubing, a small, convenient panel, and extremely precise and effective 316L stainless steel syringes.

Maintaining a small distance between the stoppering units and the vial filling reduces the possibility of contamination. The devices are designed to be utilised in sterile conditions with laminar flow protection. The un-scrambler has been redesigned to eliminate problematic locations and dead ends. An injectable liquid filler can be used to fill dosage vials with volumes ranging from 2 ml to 250 ml. From lab/pilot size to production scale, there are machines available with production output ranging from 20 VPM to 300 VPM. There are several filling pump alternatives that offer ±1% filling precision. Additionally, we provide a fully automated Vial Filler Capper and Laberler Line with our Vial Capper Machine and Vial Labeller Machine.

Working Principle of Vial Filler and Capper

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

 

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Vial Filler and Capper

Model

ALVF-40

ALVF-80

ALVF-120

ALVF – 250

Filling Heads

Two

Four

Eight

Twelve

Production Rate

Up to 40 Vials/Minute

Up to 80 Vials/Minute

Up to 150 Vials/Minute

Up to 250 Vials/Minute

Vial Diameter

15mm to 70mm

15mm to 70mm

15mm to 70mm

15mm to 70mm

Vial Height

25mm to 140mm

25mm to 140mm

25mm to 140mm

25mm to 140mm

Filling Precision

±1%

±1%

±1%

±1%

Power Required

1 H.P.

1.5 H.P.

2 H.P.

2 H.P.

Electrical Characteristics

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

Overall Dimension

2050mm (L) x 850mm (W) x 1700mm (H)

2200mm (L) x 850mm (W) x 1700mm (H)

3000mm (L) x 945mm (W) x 1700mm (H)

3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Applications of Vial Filler and Capper

Advantages of Vial Filler and Capper

Compact Monoblock Design Saves Space

Higher Production Efficiency and Output

Improved Sterility and Reduced Contamination Risk

Excellent Filling Accuracy and Product Consistency

Reduced Product Wastage and Operational Costs

Enhanced Flexibility and Easy Changeover

Better Compliance, Validation, and Ease of Maintenance

Key Features & Functions of Vial Filler and Capper

  • Peristaltic or piston pump filling for high-accuracy dosing (±0.5% or better) with no cross-contamination

 

  • Vial infeed via turntable, conveyor, or unscrambler

 

  • No-vial-no-fill / no-vial-no-stopper / no-stopper-no-cap sensors for 100% process control

 

  • Automatic stopper insertion (rubber stoppers or lyophilization stoppers)

 

  • Aluminum crimp cap or screw cap application with precise torque control

 

  • Optional nitrogen purging before and after filling (for oxygen-sensitive products)

 

  • Laminar air flow (LAF) or isolator compatibility for aseptic environments

 

  • cGMP-compliant design with 316L stainless steel contact parts and easy changeover (tool-free in many models)

 

  • PLC + HMI control with recipe management, batch reporting, and 21 CFR Part 11 compliance options

FAQ for Vial Filler and Capper

The machine typically delivers 30 to 250 vials per minute, depending on the model (e.g., two-head or multi-head configurations), vial size, and product type. For example, two-head models handle medium-scale production efficiently, while higher-head variants support high-volume commercial batches. Speed is adjustable via variable frequency drive.

It accommodates round glass vials from 5 ml to 250 ml (diameter 15–70 mm, height 25–140 mm). Fill volumes range from 50 mg to 10 grams for powders and 2 ml to 250 ml for liquids. The machine supports various rubber stopper (13–32 mm) and cap types with quick-change parts for fast format changeovers.

Filling accuracy is ±0.5% to ±1% for liquids (piston or peristaltic pumps) and ±1% to ±2% for powders (vacuum wheel system), depending on product density and consistency. Precision dosing systems, combined with “No Vial – No Filling,” ensure uniform results and minimal wastage.

The monoblock design integrates filling, stoppering, and capping with minimal distance between stations, significantly reducing open-vial exposure time and contamination risk. It operates effectively under laminar airflow, uses SS316L contact parts (autoclavable), and supports nitrogen flushing — making it ideal for aseptic processing of antibiotics, vaccines, and biologics.

Important features include the “No Vial – No Filling” and “No Vial – Machine Stop” systems, safety clutch to prevent vial breakage, individual drives for synchronized operation, digital production counter, and overload protection. Agitators (for powder) and precise cam mechanisms maintain consistent flow and accuracy throughout the process.

Yes. It is cGMP and CE compliant and meets FDA, EU-GMP, and WHO standards. Customizations include PLC with HMI, inbuilt laminar airflow, servo motors, in-process weight checking, CIP/SIP capability, and different filling systems (piston/peristaltic for liquids or vacuum wheel for powders). IQ/OQ documentation is provided for easy validation.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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