Vial Filling and Capping Machine

Q: What vial sizes and fill volumes can the machine handle?

The machine supports 2 ml to 250 ml fill volumes in round glass vials. Vial Diameter: 15 mm to 70 mm Vial Height: 25 mm to 140 mm It handles various rubber stopper sizes (13 mm to 32 mm) and aluminum flip-off or crimp caps with quick-change parts for fast format changeovers.

Q: What safety and anti-wastage features does it include?

Key features include: “No Vial – No Filling” system No Vial – No Stopper / No Stopper – No Cap sensors Digital vial counter Safety clutch mechanism Overload protection These features prevent spillage, reduce product wastage, and protect vials from breakage.

Description

Vial Filling and Capping Machine, also known as the Vial Filling Sealing Machine, is a small model used for injectable liquid vial filling, rubber stoppering, and cap sealing. Because all three processes are carried out on a single platform, this little device is also known as a combi vial filling, stoppering, and sealing machine. For compact, online tunnel-based filling line operations, this machine is the best option. Injectable vials can be filled, stoppered/bunged, and sealed with a vial filling and capping machine. For precise filling, the machine has a specifically made SS 316L filling pump. The turntable, stainless steel slat conveyor belt, and special eccentric pre-gassing, filling, and post-gassing components make up the vial filler and sealer machine. Easy-to-reach compact panels, non-toxic synthetic rubber tubing, and extremely effective and precisely constructed stainless steel 316L syringes.

The risk of contamination is decreased by the small distance between vial filling and stoppering equipment. The devices are made to be used under laminar flow protection and in a sterile environment. Dead ends and hard-to-clean areas have been removed from the un-scrambler itself. Vials with dosages ranging from 2 ml to 250 ml can be filled by an injectable liquid filling machine. There are machines available that range in production output from 20 VPM to 300 VPM, from lab/pilot scale to production scale.

Salient Features of Vial Filling and Capping Machine

2ml to 250ml fill dosage compatibility.
Compact footprint cGMP complied models.
Filling accuracy of ±1% depends upon fluid & vial types.
No cross contamination.
Easy to validate filling system for small/large batch production.
All Contact Parts Made from Stainless Steel 316L & framework by Stainless Steel 304.
Variable A.C. frequency drive for speed adjustment.

Digital Vial Counter for counting production output.
In-feed Turn Table/ Unscrambler for automatic feeding of objects.
On-line Mechanism.
“No Vial – No Filling” system feature
IQ/OQ documentation can be provided.
PLC system with Graphical User Interface. (Optional)

Working Principle of Vial Filling and Capping Machine

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Vial Filling and Capping Machine

Model	ALVF-40	ALVF-80	ALVF-120	ALVF – 250
Filling Heads	Two	Four	Eight	Twelve
Production Rate	Up to 40 Vials/Minute	Up to 80 Vials/Minute	Up to 150 Vials/Minute	Up to 250 Vials/Minute
Vial Diameter	15mm to 70mm	15mm to 70mm	15mm to 70mm	15mm to 70mm
Vial Height	25mm to 140mm	25mm to 140mm	25mm to 140mm	25mm to 140mm
Filling Precision	±1%	±1%	±1%	±1%
Power Required	1 H.P.	1.5 H.P.	2 H.P.	2 H.P.
Electrical Characteristics	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz	440 Volts, 3 Phase, 50 Hertz
Overall Dimension	2050mm (L) x 850mm (W) x 1700mm (H)	2200mm (L) x 850mm (W) x 1700mm (H)	3000mm (L) x 945mm (W) x 1700mm (H)	3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Automatic Vial Filling Machine

High Speed Vial Filling Machine

Vial Liquid Filling Machine

Vial Powder Filling Machine

Automatic Vial Filling and Rubber Stoppering Machine

Lab Scale Vial Filling Stoppering & Cap Sealing Machine

Injectable Vial Powder Filling & Stoppering Machine

Peristaltic Pump based Vial Filling Machine

Applications of Vial Filling and Capping Machine

Advantages of Vial Filling and Capping Machine

Compact Monoblock Design Saves Space

Higher Production Efficiency and Output

Improved Sterility and Reduced Contamination Risk

Excellent Filling Accuracy and Product Consistency

Reduced Product Wastage and Operational Costs

Enhanced Flexibility and Easy Changeover

Better Compliance, Validation, and Ease of Maintenance

Key Features & Functions of Vial Filling and Capping Machine

Peristaltic or piston pump filling for high-accuracy dosing (±0.5% or better) with no cross-contamination

Vial infeed via turntable, conveyor, or unscrambler

No-vial-no-fill / no-vial-no-stopper / no-stopper-no-cap sensors for 100% process control

Automatic stopper insertion (rubber stoppers or lyophilization stoppers)

Aluminum crimp cap or screw cap application with precise torque control

Optional nitrogen purging before and after filling (for oxygen-sensitive products)

Laminar air flow (LAF) or isolator compatibility for aseptic environments

cGMP-compliant design with 316L stainless steel contact parts and easy changeover (tool-free in many models)

PLC + HMI control with recipe management, batch reporting, and 21 CFR Part 11 compliance options

FAQ for Vial Filling and Capping Machine

What is a Vial Filling and Capping Machine?

A Vial Filling and Capping Machine (also called Monoblock Vial Filling, Stoppering & Sealing Machine) is a compact automatic system that performs liquid filling, rubber stoppering, and aluminum cap sealing in a single platform. It is widely used for sterile injectable liquid production in pharmaceuticals. Because all operations happen in one unit with minimal distance between stations, it reduces contamination risk significantly.

What vial sizes and fill volumes can the machine handle?

The machine supports 2 ml to 250 ml fill volumes in round glass vials.

Vial Diameter: 15 mm to 70 mm
Vial Height: 25 mm to 140 mm It handles various rubber stopper sizes (13 mm to 32 mm) and aluminum flip-off or crimp caps with quick-change parts for fast format changeovers.

What is the filling accuracy of this machine?

The Vial Filling and Capping Machine offers high filling accuracy of ±1% (depending on liquid type and vial size). It uses precision SS 316L syringes/pumps with non-return valves and an eccentric filling mechanism to ensure consistent and accurate dosing for every vial.

How does the machine maintain sterility during operation?

The machine features a very short distance between filling and stoppering stations, reducing open-vial exposure time. It is designed for operation under laminar airflow (Class 100) in sterile environments. All product contact parts are made of SS 316L, and the system supports pre- and post-gassing (nitrogen flushing) for oxygen-sensitive products.

What safety and anti-wastage features does it include?

Key features include:

“No Vial – No Filling” system
No Vial – No Stopper / No Stopper – No Cap sensors
Digital vial counter
Safety clutch mechanism
Overload protection These features prevent spillage, reduce product wastage, and protect vials from breakage.

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